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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.44 No.4

Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report

http://hdl.handle.net/10191/33183
http://hdl.handle.net/10191/33183
057ef89a-44c5-41e4-8f78-8fdec4b112a1
名前 / ファイル ライセンス アクション
44(4)_209-213.pdf 44(4)_209-213.pdf (642.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-27
タイトル
タイトル Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report
タイトル
言語 en
タイトル Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report
言語
言語 eng
キーワード
主題Scheme Other
主題 calcitonin
キーワード
主題Scheme Other
主題 granulocytosis
キーワード
主題Scheme Other
主題 lymphocytopenia
キーワード
主題Scheme Other
主題 osteoporosis
キーワード
主題Scheme Other
主題 gastrectomy
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Fukuda, Minoru

× Fukuda, Minoru

WEKO 52837

Fukuda, Minoru

Search repository
Yamamura, Soichiro

× Yamamura, Soichiro

WEKO 52838

Yamamura, Soichiro

Search repository
Hanyu, Tadamasa

× Hanyu, Tadamasa

WEKO 52839

Hanyu, Tadamasa

Search repository
Abo, Toru

× Abo, Toru

WEKO 52840

Abo, Toru

Search repository
抄録
内容記述タイプ Abstract
内容記述 Calcitonin therapy for patients with osteoporosis after gastrectomy is widely applied. Since a drug adverse reaction of this hormone is obscure, it is unknown how long the therapy can be continued or when it should be stopped. In this clinical study, it was found that patients with such osteoporosis (even after the initiation of calcitonin therapy) had a low proportion of granulocytes and a high proportion of lymphocytes in the peripheral blood. This leukocyte pattern indicates the parasympathetic nerve dominance in the hosts. When they were treated with a single injection of calcitonin, the leukocyte pattern returned transiently to a normal pattern (i.e., an increase of granulocytes), in parallel with increases in pulse rate and blood pressure (i.e., sympathetic nerve strain). Most of these changes were reversible. One typical patient who received long-term calcitonin administration and fell victim to anorexia, insomnia, cataracts, etc. (all of which are signs of sympathetic nerve strain) is then presented. During six years, of therapy, granulocytosis and lymphocytopenia were observed beginning four years after initiation. When the calcitonin therapy was ceased, all signs disappeared in parallel with normalization of the leukocyte pattern. These results suggest that an overdose of calcitonin administration manifests itself as sympathetic nerve strain, and that the leukocyte pattern in the blood is a good indicator of such reaction.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 44, 号 4, p. 209-213, 発行日 1996-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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