{"_buckets": {"deposit": "0d0f723c-6e46-4850-afad-a625625b6a59"}, "_deposit": {"id": "6421", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6421"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006421"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "213", "bibliographicPageStart": "209", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Calcitonin therapy for patients with osteoporosis after gastrectomy is widely applied. Since a drug adverse reaction of this hormone is obscure, it is unknown how long the therapy can be continued or when it should be stopped. In this clinical study, it was found that patients with such osteoporosis (even after the initiation of calcitonin therapy) had a low proportion of granulocytes and a high proportion of lymphocytes in the peripheral blood. This leukocyte pattern indicates the parasympathetic nerve dominance in the hosts. When they were treated with a single injection of calcitonin, the leukocyte pattern returned transiently to a normal pattern (i.e., an increase of granulocytes), in parallel with increases in pulse rate and blood pressure (i.e., sympathetic nerve strain). Most of these changes were reversible. One typical patient who received long-term calcitonin administration and fell victim to anorexia, insomnia, cataracts, etc. (all of which are signs of sympathetic nerve strain) is then presented. During six years, of therapy, granulocytosis and lymphocytopenia were observed beginning four years after initiation. When the calcitonin therapy was ceased, all signs disappeared in parallel with normalization of the leukocyte pattern. These results suggest that an overdose of calcitonin administration manifests itself as sympathetic nerve strain, and that the leukocyte pattern in the blood is a good indicator of such reaction.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukuda, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "52837", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "52838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanyu, Tadamasa"}], "nameIdentifiers": [{"nameIdentifier": "52839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abo, Toru"}], "nameIdentifiers": [{"nameIdentifier": "52840", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "44(4)_209-213.pdf", "filesize": [{"value": "642.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 642900.0, "url": {"label": "44(4)_209-213.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6421/files/44(4)_209-213.pdf"}, "version_id": "f23858e6-2e1b-493c-98c4-aa492136cb61"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "calcitonin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "granulocytosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lymphocytopenia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "osteoporosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastrectomy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report"}, {"subitem_title": "Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/617"], "permalink_uri": "http://hdl.handle.net/10191/33183", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-27"}, "publish_date": "2015-08-27", "publish_status": "0", "recid": "6421", "relation": {}, "relation_version_is_last": true, "title": ["Granulocytosis and Lymphocytopenia in the Blood as Indicators for Drug Adverse Reaction during Calcitonin Therapy in Patients with Osteoporosis after Gastrectomy Including a Case Report"], "weko_shared_id": null}