{"_buckets": {"deposit": "be46f7f2-d403-4315-a377-2f94ce13483c"}, "_deposit": {"id": "6395", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6395"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006395", "sets": ["456", "614"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "106", "bibliographicPageStart": "103", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Serum thrombomodulin (sTM) concentration, a marker for the endothelium, is increased by endothelial damage or by decreased renal clearance. In this study, we followed up 65 diabetic patients for more than five years to assess the relationship between complications and sTM concentrations. At the beginning, 31 of 65 patients had a high sTM concentration (≧25.9 ng/ml). In this group (the HsTM Group), prevalences of diabetic retinopathy and nephropathy amounted to 14 cases (45%) with 9 cases (29%) at the beginning, and 17 cases (55%) and 7 cases (23%) at the end of follow-up period, respectively. On the other hand, in 34 patients with normal sTM concentrations (the NsTM Group), there were 11 cases (32%) and 4 cases (12%) at the beginning, and 14 cases (41%) and 6 cases (18%) at the end of the period, respectively. There was a negative correlation between sTM and TM clearance (CTM) both for those with and without diabetic nephropathy; the sTM levels with nephropathy were higher than those without nephropathy at the same CTM, suggesting more marked endothelial damage in the patients with nephropathy than those without nephropathy. Furthermore, 11 out of 24 patients in the HsTM Group were diagnosed to have ischemic heart diseases, and 3 patients later died of myocardial infarction. On the other hand, only four out of 31 patients in the NsTM Group had ischemic heart disease. In conclusion, sTM concentration seems to be a warning marker for developing diabetic complications, especially coronary heart disease. Increased endothelial damage seems to result in increased sTM levels even in the patients with diabetic nephropathy.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tani, Nagayuki"}], "nameIdentifiers": [{"nameIdentifier": "52687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "52688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohyama, Yasuro"}], "nameIdentifiers": [{"nameIdentifier": "52689", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanyu, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "52690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "52691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "52692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Katsunori"}], "nameIdentifiers": [{"nameIdentifier": "52693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "52694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinno, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "52695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Iwao"}], "nameIdentifiers": [{"nameIdentifier": "52696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa"}], "nameIdentifiers": [{"nameIdentifier": "52697", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "45(3)_103-106.pdf", "filesize": [{"value": "465.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 465600.0, "url": {"label": "45(3)_103-106.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6395/files/45(3)_103-106.pdf"}, "version_id": "1b8d31f6-8049-46e9-bcb8-567df0d720cd"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "diabetes mellitus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thrombomodulin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ischemic heart disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Serum Thrombomodulin Concentration Is a Warning Marker for Diabetic Complications", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Serum Thrombomodulin Concentration Is a Warning Marker for Diabetic Complications"}, {"subitem_title": "Serum Thrombomodulin Concentration Is a Warning Marker for Diabetic Complications", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "614"], "permalink_uri": "http://hdl.handle.net/10191/33127", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-25"}, "publish_date": "2015-08-25", "publish_status": "0", "recid": "6395", "relation": {}, "relation_version_is_last": true, "title": ["Serum Thrombomodulin Concentration Is a Warning Marker for Diabetic Complications"], "weko_shared_id": null}