{"_buckets": {"deposit": "3ccde131-9748-46c6-93b7-05e5336017a1"}, "_deposit": {"id": "6385", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6385"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006385", "sets": ["456", "612"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "24", "bibliographicPageStart": "17", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Carbon monoxide (CO) is a candidate for neural messengers involved in synaptic plasticity. Heme oxygenase (HO), which produces carbon monoxide (CO) by oxygenation of heme, is present in neocortical pyramidal cells. In this study, we investigated the role of CO in neocortical long-term potentiation (LTP) using slices prepared from the rat auditory cortex. Tetanic stimulation of layer IV pruduced LTP of field potentials in layer II/III (LTP_II/III ) and in layer V (LTP_v ). CO (8 nM-5 ,uM) showed no significant effect on LTP_II/III , while CO significantly suppressed LTP_v at concentrations of 40 nM and 200 nM. N^G-nitro-Larginine(NA, 10 ,uM), a NO synthase inhibitor, blocked LTP_v • This blockade of LTP_v by 10,uM NA was reversed by 8-bromo-cGMP (Br-cGMP, 1 mM), a membranepermeable cyclic GMP analog. CO (40 nM) did not suppress LTP_v in the presence of 10,uM NA and 1 mM Br-cGMP. o-Aminolevulinic acid(ALA, 30,uM), which is a substrate for heme synthesis and is believed to facilitate endogenous CO production, significantly suppressed LTP_v • ALA showed no effect on LTP_II/III • These results strongly suggest that LTP_v but not LTP_II/III is suppressed by exogenous and endogenous CO probably via suppression of NO-induced cGMP formation.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Wakatsuki, Hidemitsu"}], "nameIdentifiers": [{"nameIdentifier": "52652", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kudoh, Masaharu"}], "nameIdentifiers": [{"nameIdentifier": "52653", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Kota"}], "nameIdentifiers": [{"nameIdentifier": "52654", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "52655", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuki, Katsuei"}], "nameIdentifiers": [{"nameIdentifier": "52656", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "46(1)_17-24.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "46(1)_17-24.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6385/files/46(1)_17-24.pdf"}, "version_id": "f2ec0da9-c4d0-4077-947e-fe8b12027908"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "carbon monoxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "long-term potentiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cGMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nitric oxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "auditory cortex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "o-aminolevulinic acid", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex"}, {"subitem_title": "Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "612"], "permalink_uri": "http://hdl.handle.net/10191/33074", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-21"}, "publish_date": "2015-08-21", "publish_status": "0", "recid": "6385", "relation": {}, "relation_version_is_last": true, "title": ["Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex"], "weko_shared_id": null}