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Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex
http://hdl.handle.net/10191/33074
http://hdl.handle.net/10191/3307435e7cde7-9214-4351-9b8e-6b2443780416
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(1)_17-24.pdf (1.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex | |||||
| タイトル | ||||||
| タイトル | Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | carbon monoxide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | long-term potentiation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cGMP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nitric oxide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | auditory cortex | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | o-aminolevulinic acid | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Wakatsuki, Hidemitsu
× Wakatsuki, Hidemitsu× Kudoh, Masaharu× Takahashi, Kota× Takeda, Masayuki× Shibuki, Katsuei |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carbon monoxide (CO) is a candidate for neural messengers involved in synaptic plasticity. Heme oxygenase (HO), which produces carbon monoxide (CO) by oxygenation of heme, is present in neocortical pyramidal cells. In this study, we investigated the role of CO in neocortical long-term potentiation (LTP) using slices prepared from the rat auditory cortex. Tetanic stimulation of layer IV pruduced LTP of field potentials in layer II/III (LTP_II/III ) and in layer V (LTP_v ). CO (8 nM-5 ,uM) showed no significant effect on LTP_II/III , while CO significantly suppressed LTP_v at concentrations of 40 nM and 200 nM. N^G-nitro-Larginine(NA, 10 ,uM), a NO synthase inhibitor, blocked LTP_v • This blockade of LTP_v by 10,uM NA was reversed by 8-bromo-cGMP (Br-cGMP, 1 mM), a membranepermeable cyclic GMP analog. CO (40 nM) did not suppress LTP_v in the presence of 10,uM NA and 1 mM Br-cGMP. o-Aminolevulinic acid(ALA, 30,uM), which is a substrate for heme synthesis and is believed to facilitate endogenous CO production, significantly suppressed LTP_v • ALA showed no effect on LTP_II/III • These results strongly suggest that LTP_v but not LTP_II/III is suppressed by exogenous and endogenous CO probably via suppression of NO-induced cGMP formation. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 1, p. 17-24, 発行日 1998-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Wakatsuki, Hidemitsu, Kudoh, Masaharu, Takahashi, Kota, Takeda, Masayuki, Shibuki, Katsuei, 1998, Long-term Potentiation Suppressed by Carbon Monoxide in Layer V of the Rat Auditory Cortex: Niigata University School of Medicine, 17–24 p.
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