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Immunohistochemical Identification of Thymosin β4 in Langerhans Cells in Human and Rat Skin
http://hdl.handle.net/10191/33079
http://hdl.handle.net/10191/33079d99e3c6c-f17b-4e12-98ea-7f9ac9573494
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(2)_55-62.pdf (2.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical Identification of Thymosin β4 in Langerhans Cells in Human and Rat Skin | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical Identification of Thymosin β4 in Langerhans Cells in Human and Rat Skin | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Thymosin β4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Langerhans cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | skin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | laser-microscopy | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Goto, Kazumi
× Goto, Kazumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Localization of thymosin β4(Tβ4) in human and rat skin was examined by immunohistochemistry using a monoclonal antibody against Tβ4. The specificity of the monoclonal antibody to Tβ4 was verified by Western blot analysis, where the antibody reacted to recombinant Tβ4 but not to thymosin β10(Tβ10), and stained a band corresponding to Tβ4 in the homogenate of human skin. By double immunostaining for Tβ4 and S-100 protein or by immunohistochemical staining for Tβ4 and CD1a or HLA-DR on sequential sections, the Tβ4^+ cells were identified in the epidermis as cells which also expressed S-100 protein, CD1a or HLA-DR. The findings indicate that Tβ4^+ cells in the epidermis are Langerhans cells (LC), and propose Tβ4 to be a marker of LC in the epidermis. Actinfilaments in the LC may be implicated in the migration of their progenitors from the circulation to the epidermis and in their intimate adhesion to keratinocytes. Tβ4 may play an important role in the polymerization and depolymerization of actin during these processes. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 2, p. 55-62, 発行日 1998-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Goto, Kazumi, 1998, Immunohistochemical Identification of Thymosin β4 in Langerhans Cells in Human and Rat Skin: Niigata University School of Medicine, 55–62 p.
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