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Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules
http://hdl.handle.net/10191/33089
http://hdl.handle.net/10191/330891f8722b4-fc61-42f9-b106-980feae237d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(3)_113-120.pdf (2.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules | |||||
| タイトル | ||||||
| タイトル | Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pancreas | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microcarcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | histogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53-staining | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ki-67 staining | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ki-ras mutation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Yamano, Miki
× Yamano, Miki× Watanabe, Hidenobu× Matsubayashi, Hiroyuki× Iga, Yoshiroh× Murayama, Kazuo× Matsuda, Keiji× Nishikura, Ken× Ajioka, Yoichi× Shirai, Yoshio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report an interesting case with a primary ulcerating tumor of the ampulla of Vater associated with multiple primary pancreatic ductal microadenocarcinomas. All of these pancreatic microcarcinomas (number, 69; size, 0.04-1.25mm) were histologically proved to be primary and independent of each other, and were distributed throughout the head, body, and tail of the pancreas. They were all located in the small interlobular ducts and the ductules (including intercalated ducts and centroacinar cells). Sixty-three of 69 microcarcinomas were in-situ carcinomas, and the remaining 6 were microinvasive. All microcarcinomas were well-differentiated tubular adenocarcinomas with ordinary cell phenotypes, high-grade cytologic atypia, and adjacent only to normal ordinary pancreatic ductal cells, but not to mucous cell hyperplasia. Immunohistochemically, all of the microcarcinomas showed p53-protein overexpression (p53 positive index: 91.6 ± 8.10% in 12 tumors tested), high proliferative activity (Ki-67 positive index: 64.9 ± 13.3% in the same 12 tumors), and no Ki-ras mutation detected by nested PCR-RFLP in the 12 carcinomas. We concluded that pancreatic microcarcinoma in this case arose from ordinary pancreatic ductal cells of the small ducts and ductules by way of p53 alteration without Ki-ras mutation, and that histogenesis was different from that of the more common Ki-ras-mutated carcinoma arising from metaplastic mucous cells of mucous cell hyperplasia. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 3, p. 113-120, 発行日 1998-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
