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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.46 No.3

Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules

http://hdl.handle.net/10191/33089
http://hdl.handle.net/10191/33089
1f8722b4-fc61-42f9-b106-980feae237d9
名前 / ファイル ライセンス アクション
46(3)_113-120.pdf 46(3)_113-120.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-21
タイトル
タイトル Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules
タイトル
タイトル Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 pancreas
キーワード
主題Scheme Other
主題 microcarcinoma
キーワード
主題Scheme Other
主題 histogenesis
キーワード
主題Scheme Other
主題 p53-staining
キーワード
主題Scheme Other
主題 Ki-67 staining
キーワード
主題Scheme Other
主題 Ki-ras mutation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Yamano, Miki

× Yamano, Miki

WEKO 52605

Yamano, Miki

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Watanabe, Hidenobu

× Watanabe, Hidenobu

WEKO 52606

Watanabe, Hidenobu

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Matsubayashi, Hiroyuki

× Matsubayashi, Hiroyuki

WEKO 52607

Matsubayashi, Hiroyuki

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Iga, Yoshiroh

× Iga, Yoshiroh

WEKO 52608

Iga, Yoshiroh

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Murayama, Kazuo

× Murayama, Kazuo

WEKO 52609

Murayama, Kazuo

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Matsuda, Keiji

× Matsuda, Keiji

WEKO 52610

Matsuda, Keiji

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Nishikura, Ken

× Nishikura, Ken

WEKO 52611

Nishikura, Ken

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Ajioka, Yoichi

× Ajioka, Yoichi

WEKO 52612

Ajioka, Yoichi

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Shirai, Yoshio

× Shirai, Yoshio

WEKO 52613

Shirai, Yoshio

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抄録
内容記述タイプ Abstract
内容記述 We report an interesting case with a primary ulcerating tumor of the ampulla of Vater associated with multiple primary pancreatic ductal microadenocarcinomas. All of these pancreatic microcarcinomas (number, 69; size, 0.04-1.25mm) were histologically proved to be primary and independent of each other, and were distributed throughout the head, body, and tail of the pancreas. They were all located in the small interlobular ducts and the ductules (including intercalated ducts and centroacinar cells). Sixty-three of 69 microcarcinomas were in-situ carcinomas, and the remaining 6 were microinvasive. All microcarcinomas were well-differentiated tubular adenocarcinomas with ordinary cell phenotypes, high-grade cytologic atypia, and adjacent only to normal ordinary pancreatic ductal cells, but not to mucous cell hyperplasia. Immunohistochemically, all of the microcarcinomas showed p53-protein overexpression (p53 positive index: 91.6 ± 8.10% in 12 tumors tested), high proliferative activity (Ki-67 positive index: 64.9 ± 13.3% in the same 12 tumors), and no Ki-ras mutation detected by nested PCR-RFLP in the 12 carcinomas. We concluded that pancreatic microcarcinoma in this case arose from ordinary pancreatic ductal cells of the small ducts and ductules by way of p53 alteration without Ki-ras mutation, and that histogenesis was different from that of the more common Ki-ras-mutated carcinoma arising from metaplastic mucous cells of mucous cell hyperplasia.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 46, 号 3, p. 113-120, 発行日 1998-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
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Cite as

Yamano, Miki, Watanabe, Hidenobu, Matsubayashi, Hiroyuki, Iga, Yoshiroh, Murayama, Kazuo, Matsuda, Keiji, Nishikura, Ken, Ajioka, Yoichi, Shirai, Yoshio, 1998, Primary Pancreatic Ductal Microcarcinomas Arising from Interlobular Duct and Ductules: Niigata University School of Medicine, 113–120 p.

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