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Localization of Brain-Derived Neurotrophic Factor and Neurotrophin-3 RNA Transcripts in the Brain of Reeler, Weaver and pcd Mutant Mice
http://hdl.handle.net/10191/33086
http://hdl.handle.net/10191/330860c50eef3-59c7-4a93-ae0a-28096d5636ff
名前 / ファイル | ライセンス | アクション |
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46(3)_93-99.pdf (3.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-21 | |||||
タイトル | ||||||
タイトル | Localization of Brain-Derived Neurotrophic Factor and Neurotrophin-3 RNA Transcripts in the Brain of Reeler, Weaver and pcd Mutant Mice | |||||
タイトル | ||||||
タイトル | Localization of Brain-Derived Neurotrophic Factor and Neurotrophin-3 RNA Transcripts in the Brain of Reeler, Weaver and pcd Mutant Mice | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gene expression | |||||
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主題Scheme | Other | |||||
主題 | neurological mutant mice | |||||
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主題Scheme | Other | |||||
主題 | cerebellum | |||||
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主題Scheme | Other | |||||
主題 | cerebrum | |||||
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主題Scheme | Other | |||||
主題 | BDNF | |||||
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主題Scheme | Other | |||||
主題 | NT-3 | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Triarhou, Lazaros C.
× Triarhou, Lazaros C.× Rocamora, Nati× Palacios, Jose M.× Mengod, Guadalupe |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The pattern of BDNF and neurotrophin-3 (NT-3) gene expression was analyzed in the cerebellum of wild-type (+ / +), reeler (rl/rl), weaver (wv/wv) and 'Purkinje cell degeneration' (pcd/pcd) mice by in situ hybridization histochemistry. [^<32>P] Labeled synthetic oligonucleotide DNA probes were used, complementary to bases 219-266 and 777-824 of the published mouse BDNF cDNA sequence and to bases 91-138 and 235-288 of the rat NT-3 genomic sequence. Previous developmental studies in rat cerebellum point to a possible involvement of NT-3 in early migratory and synaptogenetic events and of BDNF as a maintenance factor at later stages. In the wild-type mice, strong mRNA hybridization signals were obtained for both BDNF and NT-3 in the cerebellar granule cell layer. Reeler and weaver mice showed remarkable reductions for both BDNF and NT-3 mRNA hybridization signals in the cerebellum, which is readily explainable by the genetically-determined granule cell loss. The cerebellum of pcd mice, which primarily lose Purkinje cells, showed a slight reduction in BDNF and NT-3 mRNAs. Reeler homozygotes also showed a substantial decrease of the BDNF RNA message in the pyramidal cell layer of hippocampal CA1 field; in the cerebral cortex, the lamination was not as evident as that in normal mice. The changes recorded in BDNF and NT-3 RNA messages in these mutants are consistent with the localization of nerve cell losses. Nonetheless, their roles and possible involvement in early developmental or degenerative events remain open. These results could also suggest a coordinated down-regulation of these genes subsequent to the degeneration of Purkinje cells. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 3, p. 93-99, 発行日 1998-09 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |