WEKO3
-
RootNode
アイテム
Overexpression of p53 Protein in Hepatocellular Carcinoma : Its Definition and Correlation with Viral Infection
http://hdl.handle.net/10191/1825
http://hdl.handle.net/10191/18252d65d18a-752c-43f1-a356-dca86f770381
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007204.pdf (4.2 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Overexpression of p53 Protein in Hepatocellular Carcinoma : Its Definition and Correlation with Viral Infection | |||||
| タイトル | ||||||
| タイトル | Overexpression of p53 Protein in Hepatocellular Carcinoma : Its Definition and Correlation with Viral Infection | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 protein overexpression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 gene mutation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
WAKAI, Toshifumi
× WAKAI, Toshifumi× WATANABE, Hidenobu× SHIRAI, Yoshio× HATAKEYAMA, Katsuyoshi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND : No objective definition of p53 protein overexpression is found for hepatocellular carcinoma (HCC) in previous literature. Therefore, data on p53 status differ among investigators. The aim of this paper is to form an objective definition of p53 overexpression in HCC and assess the relationship between p53 overexpression and clinicopathological factors. METHODS : Two p53-specific monoclonal antibodies, PAb1801 and DO7,were used to compare p53 protein expression in 91 HCCs and its adjacent non-neoplastic liver tissues (91 patients), six adenomatous hyperplasias (2 patients), and 45 non-neoplastic liver tissues without tumor (45 patients). The p53 labeling index (LI) of each lesion was expressed as the number of p53 positive cells for more than 1,000 cells (range, 1006-1102 cells) in areas which counted the greatest number of positive cells in a homogeneous histological pattern. RESULTS : Of the 136 patients, 6 patients with cirrhosis and 4 patients with chronic active hepatitis showed p53-positive cells in non-neoplastic hepatocytes with DO7,but no PAb1801 positive cells were found in non-neoplastic hepatocytes in any of the cases. DO7-p53 LI of non-neoplastic hepatocytes in areas with p53-positive cells was less than 1 percent (mean±SD, 0.4±0.2%). Twenty-nine (32%) of 91 HCCs showed more than 1% p53 LI (p53 LI>1%) with either PAb1801 or DO7. The p53 LI>1% was observed in 5% (1/20) of well differentiated HCC, 33% (20/60) of moderately differentiated HCC, and 72.7% (8/11) of poorly and undifferentiated HCC. The ratio of p53 LI>1% was more frequent in patients with serological hepatitis B and/or C viral markers than in patients without these markers (P=0.003), but did not correlate with other clinicopathological factors including tumor size, portal invasion or intrahepatic metastasis. The p53 LI>1% in moderately differentiated HCCs showed a positive correlation with Ki-67 labeling index (P<0.03). CONCLUSIONS : p53 overexpression can be defined as greater than 1 percent of p53 LI, and is strongly related to viral chronic infection disease (HBV and/or HCV) and to cell proliferative activity of moderately differentiated HCCs. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 47, 号 2, p. 49-60, 発行日 1999-06 |
|||||
| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
