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Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency
http://hdl.handle.net/10191/1875
http://hdl.handle.net/10191/1875b4fda7ab-904f-4d1c-be1b-cf2949f10a8a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007218.pdf (2.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency | |||||
| タイトル | ||||||
| タイトル | Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | severe combined immunodeficiency | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytomegaloviral pneumonitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mismatched HLA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | allogeneic peripheral blood stem cell transplantation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD34^+ cells purification | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
WATANABE, Akihiro
× WATANABE, Akihiro× KAKIHARA, Toshio× KANTO, Kazunari× YAMAMOTO, Kohsuke× TANAKA, Atsushi× NUMATA, Osamu× TORIGOE, Katsumi× TOBA, Ken× UCHIYAMA, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Severe combined immunodeficiency (SCID) is a fatal congenital disorder of the immune system for which the only curative treatment is the reconstitution of the immune system by stem cell transplantation. In the case reported here we attempted the allogeneic transplantation of purified CD34^+ cells derived from granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood of the HLA-haploidentical father for a three-month-old female SCID patient, in whom both T and B cells were absent, but natural killer (NK) cells were present. Her father was administered with G-CSF (10μg/kg/day) subcutaneously for four days, and a total number of 2.3×10^7 (=4.6×10^6/kg of patient's body weight) CD34^+ cells was harvested. Purified CD34^+ cells were transplanted into the patient without preconditioning. A skin rash consistent with graft-versushost disease (GVHD) was observed on day 10 after transplantation. CD3^+ cells appeared in the peripheral blood on day 14. These findings indicate that allogeneic transplantation of purified CD34^+ cells could be one useful treatment option for SCID patients, although data from a greater number of patients will be required to draw definitive conclusions. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 47, 号 3, p. 115-120, 発行日 1999-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
