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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.47 No.3

Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency

http://hdl.handle.net/10191/1875
http://hdl.handle.net/10191/1875
b4fda7ab-904f-4d1c-be1b-cf2949f10a8a
名前 / ファイル ライセンス アクション
KJ00000007218.pdf KJ00000007218.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency
タイトル
言語 en
タイトル Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency
言語
言語 eng
キーワード
主題Scheme Other
主題 severe combined immunodeficiency
キーワード
主題Scheme Other
主題 cytomegaloviral pneumonitis
キーワード
主題Scheme Other
主題 mismatched HLA
キーワード
主題Scheme Other
主題 allogeneic peripheral blood stem cell transplantation
キーワード
主題Scheme Other
主題 CD34^+ cells purification
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 WATANABE, Akihiro

× WATANABE, Akihiro

WEKO 52490

WATANABE, Akihiro

Search repository
KAKIHARA, Toshio

× KAKIHARA, Toshio

WEKO 52491

KAKIHARA, Toshio

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KANTO, Kazunari

× KANTO, Kazunari

WEKO 52492

KANTO, Kazunari

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YAMAMOTO, Kohsuke

× YAMAMOTO, Kohsuke

WEKO 52493

YAMAMOTO, Kohsuke

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TANAKA, Atsushi

× TANAKA, Atsushi

WEKO 52494

TANAKA, Atsushi

Search repository
NUMATA, Osamu

× NUMATA, Osamu

WEKO 52495

NUMATA, Osamu

Search repository
TORIGOE, Katsumi

× TORIGOE, Katsumi

WEKO 52496

TORIGOE, Katsumi

Search repository
TOBA, Ken

× TOBA, Ken

WEKO 52497

TOBA, Ken

Search repository
UCHIYAMA, Makoto

× UCHIYAMA, Makoto

WEKO 52498

UCHIYAMA, Makoto

Search repository
抄録
内容記述タイプ Abstract
内容記述 Severe combined immunodeficiency (SCID) is a fatal congenital disorder of the immune system for which the only curative treatment is the reconstitution of the immune system by stem cell transplantation. In the case reported here we attempted the allogeneic transplantation of purified CD34^+ cells derived from granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood of the HLA-haploidentical father for a three-month-old female SCID patient, in whom both T and B cells were absent, but natural killer (NK) cells were present. Her father was administered with G-CSF (10μg/kg/day) subcutaneously for four days, and a total number of 2.3×10^7 (=4.6×10^6/kg of patient's body weight) CD34^+ cells was harvested. Purified CD34^+ cells were transplanted into the patient without preconditioning. A skin rash consistent with graft-versushost disease (GVHD) was observed on day 10 after transplantation. CD3^+ cells appeared in the peripheral blood on day 14. These findings indicate that allogeneic transplantation of purified CD34^+ cells could be one useful treatment option for SCID patients, although data from a greater number of patients will be required to draw definitive conclusions.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 47, 号 3, p. 115-120, 発行日 1999-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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