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Rat 3Y1 Cell Retains Suppressive Activity for HTLV-I TAX-mediated Transformation
http://hdl.handle.net/10191/1823
http://hdl.handle.net/10191/1823ed76850e-47c9-4b50-884b-54d9e0e699aa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007226.pdf (3.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Rat 3Y1 Cell Retains Suppressive Activity for HTLV-I TAX-mediated Transformation | |||||
| タイトル | ||||||
| タイトル | Rat 3Y1 Cell Retains Suppressive Activity for HTLV-I TAX-mediated Transformation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat 3Y1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tax | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transformation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CREB | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ATF | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NF-κB | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
SAKURAI, Mamoru
× SAKURAI, Mamoru× YAMAOKA, Shoji× TANAKA, Atsushi× HATANAKA, Masakazu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tax is an own transcriptional activator of human T-cell leukemia virus type I (HTLV-I) virus which is a causative agent of adult T-cell leukemia (ATL). Expression of the Tax protein in the rodent fibrolast, Rat-l cells, leads to an anchorage independent growth in soft agar and tumor formation in athymic mice. Rat 3Y1 cells, originating from Fisher Rat fibroblasts, are known to be a permanent cell line exhibiting a normal phenotype and have been used for assays of transformation by several oncogenes. Although Tax was able to trans-activate satisfactorily the HTLV-I long terminal repeat (LTR) and NF-κB dependent promoter in 3Y1 cells, the cells expressing Tax could neither form visible colonies in soft agar nor elicit tumors in nude mice. Cell fusion experiments suggested that 3Y1 cells might have some dominant suppressive activities for Tax-mediated transformation. Since the constitutive activation of the NF-κB pathway is suggested to be responsible for Tax-mediated transformation of rat fibroblasts, 3Y1 cells might be useful materials to obtain suppressor candidates related to the NF-κB family involved in oncogenic properties or to elucidate other unknown pathways for Tax-mediated transformation of the rat fibroblast. At least p53 mutation is not involved in cooperation with interaction of tax gene for transformation. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 47, 号 4, p. 139-146, 発行日 1999-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
