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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.47 No.4

Cancer Immunogene Therapy

http://hdl.handle.net/10191/1894
http://hdl.handle.net/10191/1894
1a4dcf64-1972-4daf-9f75-df94bfa7c567
名前 / ファイル ライセンス アクション
KJ00000007225.pdf KJ00000007225.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Cancer Immunogene Therapy
タイトル
言語 en
タイトル Cancer Immunogene Therapy
言語
言語 eng
キーワード
主題Scheme Other
主題 Immunotherapy
キーワード
主題Scheme Other
主題 transfection
キーワード
主題Scheme Other
主題 cytokine
キーワード
主題Scheme Other
主題 costimulatory molecule
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 YOSHIZAWA, Hirohisa

× YOSHIZAWA, Hirohisa

WEKO 52448

YOSHIZAWA, Hirohisa

Search repository
GEJYO, Fumitake

× GEJYO, Fumitake

WEKO 52449

GEJYO, Fumitake

Search repository
抄録
内容記述タイプ Abstract
内容記述 The identification and characterization of tumor antigens as well as the expansion of knowledge on the cellular and molecular mechanisms of antigen recognition by the immune system have raised the possibility of using immunotherapy to treat certain tumors. Information on these mechanisms has been obtained in three crucial areas : 1) the role of cytokines in the regulation of the immune response; 2) the molecular characterization of tumor antigens in both mouse and human tumors; 3) the molecular mechanisms of T cell activation and antigen presentation. Such information has provided new insight into tumor immunology and immunotherapy. Furthermore, recombinant DNA technology allows for modification of the genome of mammalian cells for therapeutic purposes in several diseases. Several novel strategies have been developed to derive genetically modified tumor cells and use them as cellular vaccines to induce antitumor immunity in animal tumor models. This combined modality of genetically modified tumor cells and immunotherapy has been termed the immunogene therapy of tumors. Crucial to this approach has been the ability to transfer into normal or neoplastic cells, genes known to increase the immunogenicity of cells, which subsequently can be used to augment immune reactions in tumor-bearing mice or cancer patients. While there has been success in inducing antitumor immunity in some tumor models, there are difficulties and limitations in the application of these gene-modified tumor cells for the treatment of preexisting tumors. In this review, recent progress in cancer immunogene therapy is discussed.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 47, 号 4, p. 131-137, 発行日 1999-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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