{"_buckets": {"deposit": "99cc79ac-2723-4cbe-ac1f-e24eb260c45b"}, "_deposit": {"id": "6337", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6337"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006337", "sets": ["456", "604"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "38", "bibliographicPageStart": "31", "bibliographicVolumeNumber": "48", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "β-amyloid-filled osmotic minipumps were used for 14-day intracerebroventricular infusion in rats, followed by routine housing for \u003e1 year. Extracellular recording of evoked potentials from cortical slices from β-amyloid-treated animals showed abnormal elicitation of long-term depression. Whereas no statistically significant difference could be found between β-amyloid-treated and control groups in cortical membrane protein kinase C activity, the use of infrared spectroscopy provided some evidence of alterations in the structure of tissue proteins and an increase in the content of acidic amino acids. The results suggest that the combination of β-amyloid infusion and normal aging may result in an animal model possessing certain functional and structural features useful for study, which may help illuminate some of the etiologies relevant to Alzheimer\u0027s disease.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "HICKS, T.P."}], "nameIdentifiers": [{"nameIdentifier": "52431", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KRASTENIAKOV, N.V."}], "nameIdentifiers": [{"nameIdentifier": "52432", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "JACKSON, M."}], "nameIdentifiers": [{"nameIdentifier": "52433", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "DONNELLY, S.M."}], "nameIdentifiers": [{"nameIdentifier": "52434", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "CHAKRAVARTHY, B."}], "nameIdentifiers": [{"nameIdentifier": "52435", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OHANNESSIAN, L."}], "nameIdentifiers": [{"nameIdentifier": "52436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKA, J.-I."}], "nameIdentifiers": [{"nameIdentifier": "52437", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007243.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "KJ00000007243.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6337/files/KJ00000007243.pdf"}, "version_id": "d2f4aa2c-8717-448e-957b-d85ebfa0131b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "β-amyloid protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Alzheimer\u0027s disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "synaptic plasticity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat cortex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "infrared spectroscopy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protein kinase C", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats"}, {"subitem_title": "Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "604"], "permalink_uri": "http://hdl.handle.net/10191/1952", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6337", "relation": {}, "relation_version_is_last": true, "title": ["Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats"], "weko_shared_id": null}