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Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats
http://hdl.handle.net/10191/1952
http://hdl.handle.net/10191/19527cfa0a40-f219-4824-8b5d-79c09193dd13
名前 / ファイル | ライセンス | アクション |
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KJ00000007243.pdf (2.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-amyloid protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alzheimer's disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synaptic plasticity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat cortex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | infrared spectroscopy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein kinase C | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
HICKS, T.P.
× HICKS, T.P.× KRASTENIAKOV, N.V.× JACKSON, M.× DONNELLY, S.M.× CHAKRAVARTHY, B.× OHANNESSIAN, L.× OKA, J.-I. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | β-amyloid-filled osmotic minipumps were used for 14-day intracerebroventricular infusion in rats, followed by routine housing for >1 year. Extracellular recording of evoked potentials from cortical slices from β-amyloid-treated animals showed abnormal elicitation of long-term depression. Whereas no statistically significant difference could be found between β-amyloid-treated and control groups in cortical membrane protein kinase C activity, the use of infrared spectroscopy provided some evidence of alterations in the structure of tissue proteins and an increase in the content of acidic amino acids. The results suggest that the combination of β-amyloid infusion and normal aging may result in an animal model possessing certain functional and structural features useful for study, which may help illuminate some of the etiologies relevant to Alzheimer's disease. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 1, p. 31-38, 発行日 2000-03 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |