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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.48 No.1

Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats

http://hdl.handle.net/10191/1952
http://hdl.handle.net/10191/1952
7cfa0a40-f219-4824-8b5d-79c09193dd13
名前 / ファイル ライセンス アクション
KJ00000007243.pdf KJ00000007243.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats
タイトル
言語 en
タイトル Altered Electrophysiological Expression of Synaptic Plasticity and Infrared Spectroscopic Tissue Composition in Long-termβ-Amyloid-treated Rats
言語
言語 eng
キーワード
主題Scheme Other
主題 β-amyloid protein
キーワード
主題Scheme Other
主題 Alzheimer's disease
キーワード
主題Scheme Other
主題 synaptic plasticity
キーワード
主題Scheme Other
主題 rat cortex
キーワード
主題Scheme Other
主題 infrared spectroscopy
キーワード
主題Scheme Other
主題 protein kinase C
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 HICKS, T.P.

× HICKS, T.P.

WEKO 52431

HICKS, T.P.

Search repository
KRASTENIAKOV, N.V.

× KRASTENIAKOV, N.V.

WEKO 52432

KRASTENIAKOV, N.V.

Search repository
JACKSON, M.

× JACKSON, M.

WEKO 52433

JACKSON, M.

Search repository
DONNELLY, S.M.

× DONNELLY, S.M.

WEKO 52434

DONNELLY, S.M.

Search repository
CHAKRAVARTHY, B.

× CHAKRAVARTHY, B.

WEKO 52435

CHAKRAVARTHY, B.

Search repository
OHANNESSIAN, L.

× OHANNESSIAN, L.

WEKO 52436

OHANNESSIAN, L.

Search repository
OKA, J.-I.

× OKA, J.-I.

WEKO 52437

OKA, J.-I.

Search repository
抄録
内容記述タイプ Abstract
内容記述 β-amyloid-filled osmotic minipumps were used for 14-day intracerebroventricular infusion in rats, followed by routine housing for >1 year. Extracellular recording of evoked potentials from cortical slices from β-amyloid-treated animals showed abnormal elicitation of long-term depression. Whereas no statistically significant difference could be found between β-amyloid-treated and control groups in cortical membrane protein kinase C activity, the use of infrared spectroscopy provided some evidence of alterations in the structure of tissue proteins and an increase in the content of acidic amino acids. The results suggest that the combination of β-amyloid infusion and normal aging may result in an animal model possessing certain functional and structural features useful for study, which may help illuminate some of the etiologies relevant to Alzheimer's disease.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 48, 号 1, p. 31-38, 発行日 2000-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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