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Extracellular recording of evoked potentials from cortical slices from \u03b2-amyloid-treated animals showed abnormal elicitation of long-term depression. Whereas no statistically significant difference could be found between \u03b2-amyloid-treated and control groups in cortical membrane protein kinase C activity, the use of infrared spectroscopy provided some evidence of alterations in the structure of tissue proteins and an increase in the content of acidic amino acids. 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