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Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice
http://hdl.handle.net/10191/1908
http://hdl.handle.net/10191/1908355eaab8-aa99-448b-b5a6-549d8ef9a394
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007252.pdf (3.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice | |||||
| タイトル | ||||||
| タイトル | Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Catharanthus roseus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methanolic leaf extract (MLCR) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | folklore medicine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypoglycaemic effects | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diabetic conditions | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
OJEWOLE, John A. O.
× OJEWOLE, John A. O.× ADEWUNMI, Clement O. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In Southern Africa, as in many other parts of Africa, Catharanthus roseus (Linn.) G. Don is traditionally used in forklore medicine to treat diabetes and a number of other human ailments. Consequently, the hypoglycaemic effects of methanolic leaf extract of C. roseus have been investigated in streptozotocin (STZ)-induced diabetic (hyperglycaemic) mice as well as in normal (normoglycaemic), STZ-untreated mice. Tolbutamide has been used as reference hypoglycaemic agent. While tolbutamide produced highly significant reductions (P<0.01-0.001) in the plasma blood glucose levels of normal (normoglycaemic) mice, the leaf extract of C. roseus produced only a relatively slight hypoglycaemic effect in the normal (normoglycaemic) animals. Data obtained in this study further showed that, following acute and/or sub-acute administrations, the methanolic leaf extract of C. roseus (MLCR, 500 mgkg^<-1> p.o.), like tolbutamide (500 mgkg^<-1> p.o.), produced highly significant hypoglycaemic effects (P<0.01-0.001) in STZ-induced diabetic mice. The hypoglycaemic effect of the plant extract was found to be more pronounced in diabetic (hyperglycaemic) mice than in normal (normoglycaemic) animals. Although the exact mechanism of the hypoglycaemic action of the plant extract remains speculative and will have to await further studies, the results of the present investigation tend to support the folkloric use of C. roseus in diabetic conditions. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 2, p. 55-58, 発行日 2000-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
