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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.48 No.2

Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice

http://hdl.handle.net/10191/1908
http://hdl.handle.net/10191/1908
355eaab8-aa99-448b-b5a6-549d8ef9a394
名前 / ファイル ライセンス アクション
KJ00000007252.pdf KJ00000007252.pdf (3.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice
タイトル
言語 en
タイトル Hypoglycaemic Effects of Methanolic Leaf Extract of Catharanthus Roseus (LINN.) G. DON (Apocynaceae) in Normal and Diabetic Mice
言語
言語 eng
キーワード
主題Scheme Other
主題 Catharanthus roseus
キーワード
主題Scheme Other
主題 methanolic leaf extract (MLCR)
キーワード
主題Scheme Other
主題 folklore medicine
キーワード
主題Scheme Other
主題 hypoglycaemic effects
キーワード
主題Scheme Other
主題 diabetic conditions
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 OJEWOLE, John A. O.

× OJEWOLE, John A. O.

WEKO 52378

OJEWOLE, John A. O.

Search repository
ADEWUNMI, Clement O.

× ADEWUNMI, Clement O.

WEKO 52379

ADEWUNMI, Clement O.

Search repository
抄録
内容記述タイプ Abstract
内容記述 In Southern Africa, as in many other parts of Africa, Catharanthus roseus (Linn.) G. Don is traditionally used in forklore medicine to treat diabetes and a number of other human ailments. Consequently, the hypoglycaemic effects of methanolic leaf extract of C. roseus have been investigated in streptozotocin (STZ)-induced diabetic (hyperglycaemic) mice as well as in normal (normoglycaemic), STZ-untreated mice. Tolbutamide has been used as reference hypoglycaemic agent. While tolbutamide produced highly significant reductions (P<0.01-0.001) in the plasma blood glucose levels of normal (normoglycaemic) mice, the leaf extract of C. roseus produced only a relatively slight hypoglycaemic effect in the normal (normoglycaemic) animals. Data obtained in this study further showed that, following acute and/or sub-acute administrations, the methanolic leaf extract of C. roseus (MLCR, 500 mgkg^<-1> p.o.), like tolbutamide (500 mgkg^<-1> p.o.), produced highly significant hypoglycaemic effects (P<0.01-0.001) in STZ-induced diabetic mice. The hypoglycaemic effect of the plant extract was found to be more pronounced in diabetic (hyperglycaemic) mice than in normal (normoglycaemic) animals. Although the exact mechanism of the hypoglycaemic action of the plant extract remains speculative and will have to await further studies, the results of the present investigation tend to support the folkloric use of C. roseus in diabetic conditions.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 48, 号 2, p. 55-58, 発行日 2000-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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