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The Elevation of Plasma Thrombomodulin in Patients with Infectious Diseases, and its Relationship to Granulocyte Elastase and Coagulation Parameters at the Early Phase of Infection
http://hdl.handle.net/10191/1819
http://hdl.handle.net/10191/1819728f2806-5069-4660-86bb-235e9f8d4caa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007250.pdf (5.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | The Elevation of Plasma Thrombomodulin in Patients with Infectious Diseases, and its Relationship to Granulocyte Elastase and Coagulation Parameters at the Early Phase of Infection | |||||
| タイトル | ||||||
| タイトル | The Elevation of Plasma Thrombomodulin in Patients with Infectious Diseases, and its Relationship to Granulocyte Elastase and Coagulation Parameters at the Early Phase of Infection | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | thrombomodulin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | infection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelial cell damage | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | granulocyte elastase | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
SEKI, Yoshinobu
× SEKI, Yoshinobu× TAKAHASHI, Hoyu× AIZAWA, Yoshifusa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives : The plasma thrombomodulin (TM) level is thought to be an indicator of endothelial cell damage. Plasma TM levels were measured along with other parameters in 153 patients with various infectious diseases. The clinical significance of plasma TM was assessed to evaluate the endothelial cell damage in infection. Design : A retrospective study of patients with infectious diseases. Setting : Out-patient and inpatient clinics at the hospital of the Niigata University School of Medicine and other hospitals. Patients : The patients' median age was 68 years. There were 95 patients with a respiratory tract infection, 10 with a biliary tract infection, 33 with a gastrointestinal infection, 8 with a urinary tract infection, and 7 with other infections. Patients having such complications as disseminated intravascular coagulation, diabetes mellitus, cerebrovascular disease, cancer, and renal dysfunction (serum creatinine>110μmolL^<-1>) or those undergoing anticoagulant therapy were excluded. Results : The plasma levels of TM, thrombin-antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), fibrin degradation products (FDP), crosslinked fibrin degradation products (D-dimer), fibrinogen, von Willebrand factor antigen (vWf : Ag) and granulocyte elastase-α1-proteinase inhibitor complex were elevated, and those of antithrombin III and protein C were decreased in these patients. The plasma TM correlated positively with the granulocyte counts, suggesting the participation of granulocytes in the endothelial cell damage. The plasma TM also correlated positively with PIC, FDP, D-dimer and vWf : Ag, and negatively with protein C. These changes were more marked in the older patients. Conclusions : Endothelial cell damage and the activation of blood coagulation and fibrinolysis were found in patients with infectious diseases. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 2, p. 45-50, 発行日 2000-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
SEKI, Yoshinobu, TAKAHASHI, Hoyu, AIZAWA, Yoshifusa, 2000, The Elevation of Plasma Thrombomodulin in Patients with Infectious Diseases, and its Relationship to Granulocyte Elastase and Coagulation Parameters at the Early Phase of Infection: Niigata University School of Medicine, 45–50 p.
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