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Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC
http://hdl.handle.net/10191/1945
http://hdl.handle.net/10191/1945db3026d7-0016-45b7-9e1b-d3e4ad580c0b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007297.pdf (2.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC | |||||
| タイトル | ||||||
| タイトル | Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sinusoidal endothelial cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kupffer cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endotoxin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | liver injury | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tumor necrosis factor | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
SATO, Yoshinobu
× SATO, Yoshinobu× TAKAGI, Kentaro× HATAKEYAMA, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Preoperative management in cirrhotic patients is extremely important to the liver surgeon in terms of preventing postoperative organ failure and infection. In this study we investigated the effects of OK432,a streptococcal preparation that is a wellknown immunopotentiator for macrophages, in modulating the liver function of patients (9 patients) with hepatocellular carcinoma accompanied with liver cirrhosis above 20% in ICG-R15. The preoperative administration of OK432 for the patients resulted in a significant improvement in the hyaluronic acid levels (before treatment vs after treatment : 293.1±111.6 ng/ml vs 145.6±80.0 ng/ml, p=0.0008) and natural killer (NK) cell activity (before treatment vs after treatment : 24.4±21.6% vs 35.5±15.1%, p=0.0166) as well as increases in levels of HLA-DR-, CD56-, CD8-, and TCR γδ-positive lymphocytes in peripheral blood--although these data were not statistically significant. The period before the removal of the abdominal drain (10.9±16.6 days vs 26.8±11.4 days), the length of hospitalization (33.2±13.2 days vs 39.4±13.8 days, and the incidence of episodes of postoperative complications (33.3% (3/9,3 episodes) vs 66.7% (10/15,12 episodes)) in the OK432-treated group were all more favorable than those in the OK432-untreated group (15 patients). These findings suggest that the preoperative administration of OK432 in cirrhotic patients may be useful for preventing postoperative liver failure and infection through inhibition of excessive immunological reactions of Kupffer cells, the enhancement of sinusoidal endothelial cell (SEC) function, and the activation of NK cells and NKT cells. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 49, 号 2, p. 39-46, 発行日 2001-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
