ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "0316b051-9d87-4275-b441-96fce571e169"}, "_deposit": {"id": "6306", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6306"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006306", "sets": ["456", "599"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "46", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Preoperative management in cirrhotic patients is extremely important to the liver surgeon in terms of preventing postoperative organ failure and infection. In this study we investigated the effects of OK432,a streptococcal preparation that is a wellknown immunopotentiator for macrophages, in modulating the liver function of patients (9 patients) with hepatocellular carcinoma accompanied with liver cirrhosis above 20% in ICG-R15. The preoperative administration of OK432 for the patients resulted in a significant improvement in the hyaluronic acid levels (before treatment vs after treatment : 293.1±111.6 ng/ml vs 145.6±80.0 ng/ml, p=0.0008) and natural killer (NK) cell activity (before treatment vs after treatment : 24.4±21.6% vs 35.5±15.1%, p=0.0166) as well as increases in levels of HLA-DR-, CD56-, CD8-, and TCR γδ-positive lymphocytes in peripheral blood--although these data were not statistically significant. The period before the removal of the abdominal drain (10.9±16.6 days vs 26.8±11.4 days), the length of hospitalization (33.2±13.2 days vs 39.4±13.8 days, and the incidence of episodes of postoperative complications (33.3% (3/9,3 episodes) vs 66.7% (10/15,12 episodes)) in the OK432-treated group were all more favorable than those in the OK432-untreated group (15 patients). These findings suggest that the preoperative administration of OK432 in cirrhotic patients may be useful for preventing postoperative liver failure and infection through inhibition of excessive immunological reactions of Kupffer cells, the enhancement of sinusoidal endothelial cell (SEC) function, and the activation of NK cells and NKT cells.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SATO, Yoshinobu"}], "nameIdentifiers": [{"nameIdentifier": "52250", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKAGI, Kentaro"}], "nameIdentifiers": [{"nameIdentifier": "52251", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HATAKEYAMA, Katsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "52252", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007297.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "KJ00000007297.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6306/files/KJ00000007297.pdf"}, "version_id": "3de07487-0c94-457d-9c04-de7723d2c01e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "sinusoidal endothelial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kupffer cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endotoxin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liver injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor necrosis factor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC"}, {"subitem_title": "Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "599"], "permalink_uri": "http://hdl.handle.net/10191/1945", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6306", "relation": {}, "relation_version_is_last": true, "title": ["Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.49 No.2

Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC

http://hdl.handle.net/10191/1945
http://hdl.handle.net/10191/1945
db3026d7-0016-45b7-9e1b-d3e4ad580c0b
名前 / ファイル ライセンス アクション
KJ00000007297.pdf KJ00000007297.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC
タイトル
言語 en
タイトル Improvement in Host Immunity and a Decrease in Morbidity by the Preoperative Administration of OK432 in Cirrhotic Patients with HCC
言語
言語 eng
キーワード
主題Scheme Other
主題 sinusoidal endothelial cell
キーワード
主題Scheme Other
主題 Kupffer cell
キーワード
主題Scheme Other
主題 endotoxin
キーワード
主題Scheme Other
主題 liver injury
キーワード
主題Scheme Other
主題 tumor necrosis factor
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 SATO, Yoshinobu

× SATO, Yoshinobu

WEKO 52250

SATO, Yoshinobu

Search repository
TAKAGI, Kentaro

× TAKAGI, Kentaro

WEKO 52251

TAKAGI, Kentaro

Search repository
HATAKEYAMA, Katsuyoshi

× HATAKEYAMA, Katsuyoshi

WEKO 52252

HATAKEYAMA, Katsuyoshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Preoperative management in cirrhotic patients is extremely important to the liver surgeon in terms of preventing postoperative organ failure and infection. In this study we investigated the effects of OK432,a streptococcal preparation that is a wellknown immunopotentiator for macrophages, in modulating the liver function of patients (9 patients) with hepatocellular carcinoma accompanied with liver cirrhosis above 20% in ICG-R15. The preoperative administration of OK432 for the patients resulted in a significant improvement in the hyaluronic acid levels (before treatment vs after treatment : 293.1±111.6 ng/ml vs 145.6±80.0 ng/ml, p=0.0008) and natural killer (NK) cell activity (before treatment vs after treatment : 24.4±21.6% vs 35.5±15.1%, p=0.0166) as well as increases in levels of HLA-DR-, CD56-, CD8-, and TCR γδ-positive lymphocytes in peripheral blood--although these data were not statistically significant. The period before the removal of the abdominal drain (10.9±16.6 days vs 26.8±11.4 days), the length of hospitalization (33.2±13.2 days vs 39.4±13.8 days, and the incidence of episodes of postoperative complications (33.3% (3/9,3 episodes) vs 66.7% (10/15,12 episodes)) in the OK432-treated group were all more favorable than those in the OK432-untreated group (15 patients). These findings suggest that the preoperative administration of OK432 in cirrhotic patients may be useful for preventing postoperative liver failure and infection through inhibition of excessive immunological reactions of Kupffer cells, the enhancement of sinusoidal endothelial cell (SEC) function, and the activation of NK cells and NKT cells.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 49, 号 2, p. 39-46, 発行日 2001-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:41:46.604806
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3