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Relation of Apolipoprotein E Polymorphism to Serum Lipid Profiles in Obese Children
http://hdl.handle.net/10191/1858
http://hdl.handle.net/10191/1858435a2f2e-6d43-4f96-b193-098cd84c0459
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00001015039.pdf (4.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Relation of Apolipoprotein E Polymorphism to Serum Lipid Profiles in Obese Children | |||||
| タイトル | ||||||
| タイトル | Relation of Apolipoprotein E Polymorphism to Serum Lipid Profiles in Obese Children | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | obese children | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apolipoprotein E | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apoE4 allele | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apolipoprotein B | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
ASAMI, Tadashi
× ASAMI, Tadashi× CIOMARTEN, Tatiana× ITOH, Sueshi× UCHIYAMA, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Obesity is a risk factor for future atherosclerosis in children. Apolipoprotein B (apoB) is the principal apolipoprotein of low-density lipoprotein, which is one of causative factors of atherosclerosis, and apolipoprotein E ε4 allele (apoE4) allele has been considered to be a risk factor for coronary artery diseases. We investigated the influence of apoE polymorphism on lipid and apolipoprotein levels in obese children. Thirtyseven Japanese obese children with a mean age of 10.1 years and 134 normal children were included in the study. Serum lipids and apolipoproteins were measured by an autoanalyzer, and apoE phenotyping was performed by isoelectric focusing of delipidated serum samples on polyacrylamide gel followed by immunoblotting. The Stat-View statistical computer package was used for data processing. Obese children with at least one apoE4 allele had significantly higher apoB levels and apoB/apoA-I ratios than E3 homozygotes (p=0.0080 and p=0.0104,respectively). Frequencies of apoE phenotypes and alleles in the obese children were not different from those in normal children. Obese children with at least one apoE4 allele had higher apoB levels and apoB/apoA-I ratios. It is suggested that obese children with at least one apoE4 allele are at a higher risk for future atherosclerosis than those without it. ApoE phenotyping may be a useful clinical test for identifying obese children who require more careful management. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 49, 号 3-4, p. 89-94, 発行日 2001-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
