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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.50 No.1

Chemical Deafferentation of the Nasal Neuroepithelium Profoundly Reduces Cholecystokinin Gene Expression in the Mouse Olfactory Bulb

http://hdl.handle.net/10191/1835
http://hdl.handle.net/10191/1835
5d2ba843-7a15-49ef-af45-3951c25d6bea
名前 / ファイル ライセンス アクション
KJ00000007312.pdf KJ00000007312.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Chemical Deafferentation of the Nasal Neuroepithelium Profoundly Reduces Cholecystokinin Gene Expression in the Mouse Olfactory Bulb
タイトル
言語 en
タイトル Chemical Deafferentation of the Nasal Neuroepithelium Profoundly Reduces Cholecystokinin Gene Expression in the Mouse Olfactory Bulb
言語
言語 eng
キーワード
主題Scheme Other
主題 chemical deafferentation
キーワード
主題Scheme Other
主題 olfactory bulb
キーワード
主題Scheme Other
主題 CCK mRNA
キーワード
主題Scheme Other
主題 in situ hybridization
キーワード
主題Scheme Other
主題 tufted cell
キーワード
主題Scheme Other
主題 mitral cell
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 KOZAKAI, Ikuo

× KOZAKAI, Ikuo

WEKO 52221

KOZAKAI, Ikuo

Search repository
ITOH, Yasuhiro

× ITOH, Yasuhiro

WEKO 52222

ITOH, Yasuhiro

Search repository
KUWANO, Ryozo

× KUWANO, Ryozo

WEKO 52223

KUWANO, Ryozo

Search repository
AOYAGI, Yutaka

× AOYAGI, Yutaka

WEKO 52224

AOYAGI, Yutaka

Search repository
ASAKURA, Hitoshi

× ASAKURA, Hitoshi

WEKO 52225

ASAKURA, Hitoshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 A denervation study was carried out to determine whether damage to the neuronal perikarya in the primary olfactory pathway alters the transneuronal level of cholecystokinin (CCK) mRNA expression. The time course study of denervation-induced change in CCK mRNA expression was done using northern blot and in situ hybridization methods. Northern blot analysis revealed a significant reduction in CCK mRNA expression. The quantified radioactive orbital densities in the olfactory bulb in the control at 48 hours, 7 days, and 14 days after the denervation were 1025 (100%), 743 (72%)/513 (50%), 358 (35%)/498 (49%) and 325 (32%)/338 (33%) photo-stimulated luminescence, respectively. In situ hybridization indicated that CCK expression in external tufted cells and middle tufted cells decreased time-dependently, reaching 76% of the control levels at 48 hours, 45% at 7 days, 26% at 14 days, and 15% at 30 days, respectively. CCK mRNA was expressed also in the deep tufted cells and mitral cells. Low-power darkfield photomicrography revealed that deep tufted cells and mitral cells did not undergo a profound decrease as seen in the external and middle tufted cells. These data suggest that CCK mRNA expression is differentially controlled by cell subpopulations in the olfactory bulb after deafferentation.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 50, 号 1, p. 53-60, 発行日 2002-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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