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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.50 No.1

Haplotypes of BRCA1 Mutation Alleles in Japanese Ovarian and Breast-Ovarian Cancer Families: A Novel Method for Detecting BRCA1 Associated Ovarian Cancer

http://hdl.handle.net/10191/1930
http://hdl.handle.net/10191/1930
eca90569-372e-43c3-9920-aefaa262987d
名前 / ファイル ライセンス アクション
KJ00000007310.pdf KJ00000007310.pdf (7.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Haplotypes of BRCA1 Mutation Alleles in Japanese Ovarian and Breast-Ovarian Cancer Families: A Novel Method for Detecting BRCA1 Associated Ovarian Cancer
タイトル
言語 en
タイトル Haplotypes of BRCA1 Mutation Alleles in Japanese Ovarian and Breast-Ovarian Cancer Families: A Novel Method for Detecting BRCA1 Associated Ovarian Cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 Familial ovarian cancer
キーワード
主題Scheme Other
主題 Sporadic ovarian cancer
キーワード
主題Scheme Other
主題 BRCA1
キーワード
主題Scheme Other
主題 LOH
キーワード
主題Scheme Other
主題 Haplotype
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 NAGATA, Hiroshi

× NAGATA, Hiroshi

WEKO 52199

NAGATA, Hiroshi

Search repository
SEKINE, Masayuki

× SEKINE, Masayuki

WEKO 52200

SEKINE, Masayuki

Search repository
TSUJI, Shoji

× TSUJI, Shoji

WEKO 52201

TSUJI, Shoji

Search repository
HIRAI, Yasuo

× HIRAI, Yasuo

WEKO 52202

HIRAI, Yasuo

Search repository
FUJIMOTO, Seiichiro

× FUJIMOTO, Seiichiro

WEKO 52203

FUJIMOTO, Seiichiro

Search repository
HATAE, Masayuki

× HATAE, Masayuki

WEKO 52204

HATAE, Masayuki

Search repository
KOBAYASHI, Iwao

× KOBAYASHI, Iwao

WEKO 52205

KOBAYASHI, Iwao

Search repository
HUJII, Tsuneo

× HUJII, Tsuneo

WEKO 52206

HUJII, Tsuneo

Search repository
NAGATA, Ichiro

× NAGATA, Ichiro

WEKO 52207

NAGATA, Ichiro

Search repository
USHIJIMA, Kimio

× USHIJIMA, Kimio

WEKO 52208

USHIJIMA, Kimio

Search repository
OBATA, Koshiro

× OBATA, Koshiro

WEKO 52209

OBATA, Koshiro

Search repository
SUZUKI, Mitsuaki

× SUZUKI, Mitsuaki

WEKO 52210

SUZUKI, Mitsuaki

Search repository
YOSHINAGA., Mitsuhiro

× YOSHINAGA., Mitsuhiro

WEKO 52211

YOSHINAGA., Mitsuhiro

Search repository
UMESAKI, Naohiko

× UMESAKI, Naohiko

WEKO 52212

UMESAKI, Naohiko

Search repository
SATOH, Shinji

× SATOH, Shinji

WEKO 52213

SATOH, Shinji

Search repository
ENOMOTO, Takayuki

× ENOMOTO, Takayuki

WEKO 52214

ENOMOTO, Takayuki

Search repository
MOTOYAMA, Satoru

× MOTOYAMA, Satoru

WEKO 52215

MOTOYAMA, Satoru

Search repository
TANAKA, Kenichi

× TANAKA, Kenichi

WEKO 52216

TANAKA, Kenichi

Search repository
The, Japanese Familial Ovarian Cancer Study Group

× The, Japanese Familial Ovarian Cancer Study Group

WEKO 52217

The, Japanese Familial Ovarian Cancer Study Group

Search repository
抄録
内容記述タイプ Abstract
内容記述 We examined 21 ovarian and 24 breastovarian cancer families with BRCA1 mutations among a Japanese population. Twenty-four kinds of mutations were observed in these families. The DNAs of the mutation carriers (including the cancer patients) with these mutations were genotyped with microsatellite markers (D17S855,D17S1322,D17S1323 and D17S1325) located around the BRCA1 gene. The microsatellite genotyping showed that the alleles with the same mutations had the same haplotypes. This suggests that patients with the same mutation may have a common ancestor. On the other hand, a loss of heterozygosity (LOH) in the 4 microsatellite markers was observed in 48 (96.0%) of 50 tumor tissues examined. A combination of microsatellite genotyping and LOH analysis revealed that DNAs of the tumors retained the alleles with haplotypes common to the patients with the same mutation. Based on these results, we speculated on which mutations would occur in ovarian cancer families, working inversely from the haplotypes determined by this combination of methods. Consequently, T307A mutation in 2 families and C2919T in 4 families could be easily found. Applying these methods, we were able to detect haplotypes of 22 mutation alleles common to persons with the same mutations. Moreover, we employed LOH analysis and discovered two patients with a germline mutation of BRCA1 among 57 ovarian cancer patients without a family history of ovarian cancer. Determination of the retained haplotype by LOH analysis was proven to be an efficient tool to detect BRCA1 mutations from both familial and non-familial ovarian cancer patients.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 50, 号 1, p. 33-42, 発行日 2002-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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