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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.50 No.2

p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct

http://hdl.handle.net/10191/1911
http://hdl.handle.net/10191/1911
a2b658a2-c178-4d45-97c1-20dabc59f751
名前 / ファイル ライセンス アクション
KJ00000007320.pdf KJ00000007320.pdf (4.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct
タイトル
タイトル p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 anomalous junction of the pancreaticobiliary duct
キーワード
主題Scheme Other
主題 gallbladder carcinoma
キーワード
主題Scheme Other
主題 p53
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Date, Kazutoshi

× Date, Kazutoshi

WEKO 52139

Date, Kazutoshi

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Watanabe, Hidenobu

× Watanabe, Hidenobu

WEKO 52140

Watanabe, Hidenobu

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Ajioka, Youichi

× Ajioka, Youichi

WEKO 52141

Ajioka, Youichi

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Shirai, Yoshio

× Shirai, Yoshio

WEKO 52142

Shirai, Yoshio

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Yokoyama, Naoyuki

× Yokoyama, Naoyuki

WEKO 52143

Yokoyama, Naoyuki

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Yoshikawa, Tatuya

× Yoshikawa, Tatuya

WEKO 52144

Yoshikawa, Tatuya

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Kasuya, Kazuhiko

× Kasuya, Kazuhiko

WEKO 52145

Kasuya, Kazuhiko

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Koyanagi, Yasuhisa

× Koyanagi, Yasuhisa

WEKO 52146

Koyanagi, Yasuhisa

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Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 52147

Hatakeyama, Katsuyoshi

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抄録
内容記述タイプ Abstract
内容記述 The purpose of this study is to clarify whether or not p53 gene mutations differ between gallbladder carcinoma (GBC) with an anomalous junction of the pancreaticobiliary duct (AJPBD) and GBC without AJPBD. We examined 17 GBCs with AJPBD and 22 GBCs without AJPBD. Immunohistochemically, the frequency of p53 protein over-expression was 64.7% in GBCs with AJPBD and 77.3% in GBCs without AJPBD. p53 mutations were found in 47.1% of GBCs with AJPBD and 50.0% of GBCs without AJPBD. The mutations were distributed from exons 5 to 8 without a preponderance in certain exons or specific mutational hot spots in either group. All mutations of GBCs with AJPBD were G : C to A : T transition, and 27.3% occurred at the CpG site. For GBCs without AJPBD, 30.3% of mutations were transversion, and mutations did not occur at the CpG site. These results indicate differences in the mutagenesis of p53 gene alteration between GBCs with AJPBD and GBCs without AJPBD.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 50, 号 2, p. 83-90, 発行日 2002-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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Cite as

Date, Kazutoshi, Watanabe, Hidenobu, Ajioka, Youichi, Shirai, Yoshio, Yokoyama, Naoyuki, Yoshikawa, Tatuya, Kasuya, Kazuhiko, Koyanagi, Yasuhisa, Hatakeyama, Katsuyoshi, 2002, p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct: Niigata University School of Medicine, 83–90 p.

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