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p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct
http://hdl.handle.net/10191/1911
http://hdl.handle.net/10191/1911a2b658a2-c178-4d45-97c1-20dabc59f751
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007320.pdf (4.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct | |||||
| タイトル | ||||||
| タイトル | p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anomalous junction of the pancreaticobiliary duct | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gallbladder carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Date, Kazutoshi
× Date, Kazutoshi× Watanabe, Hidenobu× Ajioka, Youichi× Shirai, Yoshio× Yokoyama, Naoyuki× Yoshikawa, Tatuya× Kasuya, Kazuhiko× Koyanagi, Yasuhisa× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study is to clarify whether or not p53 gene mutations differ between gallbladder carcinoma (GBC) with an anomalous junction of the pancreaticobiliary duct (AJPBD) and GBC without AJPBD. We examined 17 GBCs with AJPBD and 22 GBCs without AJPBD. Immunohistochemically, the frequency of p53 protein over-expression was 64.7% in GBCs with AJPBD and 77.3% in GBCs without AJPBD. p53 mutations were found in 47.1% of GBCs with AJPBD and 50.0% of GBCs without AJPBD. The mutations were distributed from exons 5 to 8 without a preponderance in certain exons or specific mutational hot spots in either group. All mutations of GBCs with AJPBD were G : C to A : T transition, and 27.3% occurred at the CpG site. For GBCs without AJPBD, 30.3% of mutations were transversion, and mutations did not occur at the CpG site. These results indicate differences in the mutagenesis of p53 gene alteration between GBCs with AJPBD and GBCs without AJPBD. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 50, 号 2, p. 83-90, 発行日 2002-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
