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Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation
http://hdl.handle.net/10191/1944
http://hdl.handle.net/10191/1944eff37219-e558-424c-8b03-947fdd6314dd
名前 / ファイル | ライセンス | アクション |
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KJ00000007335.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
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タイトル | Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyclosporin A | |||||
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主題Scheme | Other | |||||
主題 | endothelin-1 | |||||
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主題Scheme | Other | |||||
主題 | hypertension | |||||
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主題Scheme | Other | |||||
主題 | bone marrow transplantation | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
SEKI, Yoshinobu
× SEKI, Yoshinobu× FURUKAWA, Tatsuo× YUASA, Kazuhisa× KOIKE, Tadashi× AIZAWA, Yoshifusa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Cyclosporin-induced hypertension is considered to be a result of elevated plasma endothelin-1 (ET-1) oo sodium retention. Methods. To evaluate the function and the degree of vascular damage of endothelial cells in cyclosporininduced hypertension after allogeneic bone marrow transplantation (BMT), we continuously measured blood pressure by ambulatory blood pressure monitoring and measured plasma levels of endothelin-1 and soluble thrombomodulin (TM) together with cyclosporin A (CsA) concentration. Results. CsA level was the lowest one hour after the administration of CsA and peaked 4-6 hours after it. ET-1 levels had a similar profile to CsA levels. No change in TM levels was observed. Systolic blood pressure levels were over 140 mmHg throughout the day, and tended to rise further degree 3-4 hours after the ET-1 level rose. The presence of an immediate change in systolic blood pressure associated with ET-1 change was unclear. In contrast, another patient who had normal ET-1 levels and low concentration levels of CsA showed normal blood pressure. Conclusions. ET-1 is released from endothelial cells, probably due to cyclosporin, and may contribute to cyclosporin-induced hypertension after BMT. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 50, 号 3, p. 157-160, 発行日 2002-09 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |