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To evaluate the function and the degree of vascular damage of endothelial cells in cyclosporininduced hypertension after allogeneic bone marrow transplantation (BMT), we continuously measured blood pressure by ambulatory blood pressure monitoring and measured plasma levels of endothelin-1 and soluble thrombomodulin (TM) together with cyclosporin A (CsA) concentration. Results. CsA level was the lowest one hour after the administration of CsA and peaked 4-6 hours after it. ET-1 levels had a similar profile to CsA levels. No change in TM levels was observed. Systolic blood pressure levels were over 140 mmHg throughout the day, and tended to rise further degree 3-4 hours after the ET-1 level rose. The presence of an immediate change in systolic blood pressure associated with ET-1 change was unclear. In contrast, another patient who had normal ET-1 levels and low concentration levels of CsA showed normal blood pressure. Conclusions. 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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.50 No.3

Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation

http://hdl.handle.net/10191/1944
http://hdl.handle.net/10191/1944
eff37219-e558-424c-8b03-947fdd6314dd
名前 / ファイル ライセンス アクション
KJ00000007335.pdf KJ00000007335.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation
タイトル
言語 en
タイトル Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation
言語
言語 eng
キーワード
主題Scheme Other
主題 Cyclosporin A
キーワード
主題Scheme Other
主題 endothelin-1
キーワード
主題Scheme Other
主題 hypertension
キーワード
主題Scheme Other
主題 bone marrow transplantation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 SEKI, Yoshinobu

× SEKI, Yoshinobu

WEKO 52125

SEKI, Yoshinobu

Search repository
FURUKAWA, Tatsuo

× FURUKAWA, Tatsuo

WEKO 52126

FURUKAWA, Tatsuo

Search repository
YUASA, Kazuhisa

× YUASA, Kazuhisa

WEKO 52127

YUASA, Kazuhisa

Search repository
KOIKE, Tadashi

× KOIKE, Tadashi

WEKO 52128

KOIKE, Tadashi

Search repository
AIZAWA, Yoshifusa

× AIZAWA, Yoshifusa

WEKO 52129

AIZAWA, Yoshifusa

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background. Cyclosporin-induced hypertension is considered to be a result of elevated plasma endothelin-1 (ET-1) oo sodium retention. Methods. To evaluate the function and the degree of vascular damage of endothelial cells in cyclosporininduced hypertension after allogeneic bone marrow transplantation (BMT), we continuously measured blood pressure by ambulatory blood pressure monitoring and measured plasma levels of endothelin-1 and soluble thrombomodulin (TM) together with cyclosporin A (CsA) concentration. Results. CsA level was the lowest one hour after the administration of CsA and peaked 4-6 hours after it. ET-1 levels had a similar profile to CsA levels. No change in TM levels was observed. Systolic blood pressure levels were over 140 mmHg throughout the day, and tended to rise further degree 3-4 hours after the ET-1 level rose. The presence of an immediate change in systolic blood pressure associated with ET-1 change was unclear. In contrast, another patient who had normal ET-1 levels and low concentration levels of CsA showed normal blood pressure. Conclusions. ET-1 is released from endothelial cells, probably due to cyclosporin, and may contribute to cyclosporin-induced hypertension after BMT.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 50, 号 3, p. 157-160, 発行日 2002-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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