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E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer
http://hdl.handle.net/10191/1896
http://hdl.handle.net/10191/1896cfd3ab03-9e69-44bb-96da-b724c53227f9
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | E-cadherin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | methylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-catenin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric cancer | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
ITO, Kazushige
× ITO, Kazushige× KASUYA, Kazuhiko× AOKI, Tatsuya× TAKAGI, Yu× KATAYANAGI, So× TSUCHIDA, Akihiko× KOYANAGI, Yasuhisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The first step of cancer metastasis requires an abnormality of adhesive factors, especially E-cadherin. The causes of abnormal E-cadherin expression consist of gene mutation and methylation of its promoter. An abnormality of E-cadherin protein expression has been frequently found in infiltratively growing tumors such as breast cancers rather than in highly differentiated tumors such as colorectal cancers. However, there have been few reports about abnormal E-cadherin methylation in gastric cancer. In the present study, we examined the relationships between the abnormal expression of E-cadherin, methylation of E-cadherin, abnormal expression of α-catenin and pathological prognostic factors, tumor growth type, and distant metastasis. Materials and Methods : We evaluated the expression of E-cadherin andα-catenin immunohistochemically and the mutational status of E-cadherin methylation in 38 patients with gastric cancer. Results : Abnormal expressions of E-cadherin and α-catenin were observed in 20 cases (52.6%) and 11 cases (28.9%), respectively. The E-cadherin expression was significantly correlated with tumor growth type, histological type, depth of invasion and size of tumor. Fifteen cases were positive for E-cadherin methylation (39.5%), which was seen in cases with dissemination or tumors localized in the upper stomach (in particular the fundic gland zone). Conclusion : A decrease of either E-cadherin expression or methylation has is closely related to infiltrative tumor growth and dissemination. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 50, 号 3, p. 117-123, 発行日 2002-09 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |