ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "ec829173-eca6-4998-a41f-bf96f64dd9e7"}, "_deposit": {"id": "6282", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6282"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006282", "sets": ["456", "595"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "123", "bibliographicPageStart": "117", "bibliographicVolumeNumber": "50", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The first step of cancer metastasis requires an abnormality of adhesive factors, especially E-cadherin. The causes of abnormal E-cadherin expression consist of gene mutation and methylation of its promoter. An abnormality of E-cadherin protein expression has been frequently found in infiltratively growing tumors such as breast cancers rather than in highly differentiated tumors such as colorectal cancers. However, there have been few reports about abnormal E-cadherin methylation in gastric cancer. In the present study, we examined the relationships between the abnormal expression of E-cadherin, methylation of E-cadherin, abnormal expression of α-catenin and pathological prognostic factors, tumor growth type, and distant metastasis. Materials and Methods : We evaluated the expression of E-cadherin andα-catenin immunohistochemically and the mutational status of E-cadherin methylation in 38 patients with gastric cancer. Results : Abnormal expressions of E-cadherin and α-catenin were observed in 20 cases (52.6%) and 11 cases (28.9%), respectively. The E-cadherin expression was significantly correlated with tumor growth type, histological type, depth of invasion and size of tumor. Fifteen cases were positive for E-cadherin methylation (39.5%), which was seen in cases with dissemination or tumors localized in the upper stomach (in particular the fundic gland zone). Conclusion : A decrease of either E-cadherin expression or methylation has is closely related to infiltrative tumor growth and dissemination.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ITO, Kazushige"}], "nameIdentifiers": [{"nameIdentifier": "52098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KASUYA, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "52099", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AOKI, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "52100", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKAGI, Yu"}], "nameIdentifiers": [{"nameIdentifier": "52101", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KATAYANAGI, So"}], "nameIdentifiers": [{"nameIdentifier": "52102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TSUCHIDA, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "52103", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOYANAGI, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "52104", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007330.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "KJ00000007330.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6282/files/KJ00000007330.pdf"}, "version_id": "979db4d5-cf8e-42d8-8922-58c5689b4399"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "E-cadherin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "α-catenin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastric cancer", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer"}, {"subitem_title": "E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "595"], "permalink_uri": "http://hdl.handle.net/10191/1896", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6282", "relation": {}, "relation_version_is_last": true, "title": ["E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.50 No.3

E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer

http://hdl.handle.net/10191/1896
http://hdl.handle.net/10191/1896
cfd3ab03-9e69-44bb-96da-b724c53227f9
名前 / ファイル ライセンス アクション
KJ00000007330.pdf KJ00000007330.pdf (2.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer
タイトル
言語 en
タイトル E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 E-cadherin
キーワード
主題Scheme Other
主題 methylation
キーワード
主題Scheme Other
主題 α-catenin
キーワード
主題Scheme Other
主題 gastric cancer
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 ITO, Kazushige

× ITO, Kazushige

WEKO 52098

ITO, Kazushige

Search repository
KASUYA, Kazuhiko

× KASUYA, Kazuhiko

WEKO 52099

KASUYA, Kazuhiko

Search repository
AOKI, Tatsuya

× AOKI, Tatsuya

WEKO 52100

AOKI, Tatsuya

Search repository
TAKAGI, Yu

× TAKAGI, Yu

WEKO 52101

TAKAGI, Yu

Search repository
KATAYANAGI, So

× KATAYANAGI, So

WEKO 52102

KATAYANAGI, So

Search repository
TSUCHIDA, Akihiko

× TSUCHIDA, Akihiko

WEKO 52103

TSUCHIDA, Akihiko

Search repository
KOYANAGI, Yasuhisa

× KOYANAGI, Yasuhisa

WEKO 52104

KOYANAGI, Yasuhisa

Search repository
抄録
内容記述タイプ Abstract
内容記述 The first step of cancer metastasis requires an abnormality of adhesive factors, especially E-cadherin. The causes of abnormal E-cadherin expression consist of gene mutation and methylation of its promoter. An abnormality of E-cadherin protein expression has been frequently found in infiltratively growing tumors such as breast cancers rather than in highly differentiated tumors such as colorectal cancers. However, there have been few reports about abnormal E-cadherin methylation in gastric cancer. In the present study, we examined the relationships between the abnormal expression of E-cadherin, methylation of E-cadherin, abnormal expression of α-catenin and pathological prognostic factors, tumor growth type, and distant metastasis. Materials and Methods : We evaluated the expression of E-cadherin andα-catenin immunohistochemically and the mutational status of E-cadherin methylation in 38 patients with gastric cancer. Results : Abnormal expressions of E-cadherin and α-catenin were observed in 20 cases (52.6%) and 11 cases (28.9%), respectively. The E-cadherin expression was significantly correlated with tumor growth type, histological type, depth of invasion and size of tumor. Fifteen cases were positive for E-cadherin methylation (39.5%), which was seen in cases with dissemination or tumors localized in the upper stomach (in particular the fundic gland zone). Conclusion : A decrease of either E-cadherin expression or methylation has is closely related to infiltrative tumor growth and dissemination.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 50, 号 3, p. 117-123, 発行日 2002-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:42:15.177970
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3