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Clinical Significance of VEGF and d Thd Pase Expressions in Squamous Cell Carcinoma of the Esophagus
http://hdl.handle.net/10191/1845
http://hdl.handle.net/10191/1845cd160b4b-dc78-4f4e-832b-284e67a736fb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007375.pdf (5.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of VEGF and d Thd Pase Expressions in Squamous Cell Carcinoma of the Esophagus | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of VEGF and d Thd Pase Expressions in Squamous Cell Carcinoma of the Esophagus | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tumor angiogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | VEGF | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dThdPase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | esophageal carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | surgical oncology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | esophagectomy | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
NAKAGAWA, Satoru
× NAKAGAWA, Satoru× NISHIMAKI, Tadashi× KANDA, Tatsuo× KUWABARA, Shirou× OHASHI, Manabu× HATAKEYAMA, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: The purposes of this study were to clarify the relation between the vascular endothelial growth factor (VEGF) and thymidine phosphorylase (dThdPase) expression in tumor progression, and to evaluate the prognostic influence of these angiogenic factors in patients with esophageal cancer. Methods: VEGF and dThdPase expression and microvessel density (MVD) were immunohistochemically studied in esophageal cancer specimens resected from 103 patients by extended radical esophagectomy. The expression status of VEGF and dThdPase was compared with intratumoral MVD, clinicopathologic parameters of tumor progression, and patient survival after esophagectomy. Results: dThdPase expression was significantly correlated with depth of invasion (P=0.0249) and the size (P=0.0004) of primary tumors. VEGF expression significantly correlated with the depth (P=0.0030) and size (P=0.0345) of the primary tumor. There was no relation between dThdPase and VEGF expression status. dThdPase expression had a significant association with MVD (P=0.0203), whereas VEGF expression had no such association. The survival curves of patients did not differ according to the expression status of dThdPase and/or VEGF. Conclusions: The expression of VEGF and dThdPase was associated with the progression of esophageal cancer by different tumor angiogenic mechanisms. However, the expression of these angiogenic factors had no significant influence upon the survival of patients who underwent extended radical esophagectomy for esophageal cancer. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 51, 号 3, p. 87-95, 発行日 2003-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
NAKAGAWA, Satoru, NISHIMAKI, Tadashi, KANDA, Tatsuo, KUWABARA, Shirou, OHASHI, Manabu, HATAKEYAMA, Katsuyoshi, 2003, Clinical Significance of VEGF and d Thd Pase Expressions in Squamous Cell Carcinoma of the Esophagus: Niigata University School of Medicine, 87–95 p.
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