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The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment
http://hdl.handle.net/10191/1817
http://hdl.handle.net/10191/1817d3e2a57e-8590-4e99-90e1-928ea7b89510
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267696.pdf (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment | |||||
| タイトル | ||||||
| タイトル | The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ventricular tachycardia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | excitable gap | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transient entrainment | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dl-sotalol | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
AIZAWA, Yoshifusa
× AIZAWA, Yoshifusa× CHINUSHI, Masaomi× FURUSHIMA, Hiroshi× WATANABE, Hiroshi× TANABE, Yasutaka× SUGIURA, Hirotaka× HIRONO, Takashi× FUJITA, Satoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aims: In selecting effective antiarrhythmic agents for reentrant ventricular tachycardia (VT), there is no hallmark which can predict drug-efficacy. In this study, the ability of dl-sotalol to suppress the inducible VT was assessed during an electrophysiologic study with special reference to the zone of entrainment, an index of the excitable gap. Methods and Results: In 21 patients, monomorphic sustained VT was induced and entrained with rapid ventricular pacing at progressively shorter cycle lengths until VT was terminated at a critical length (=block cycle length) and the width of the zone of entrainment was calculated as the difference between the cycle length of VT and the VT-interrupting critical cycle length: the longest cycle length at which 1:1 conduction fails within the zone of slow conduction. The effective refractory period was measured by extrastimulus technique. After the administration of dlsotalol (240-320mg/day for>14 days), the drug efficacy was evaluated by an electrophysiologic study and the relation to the basal electrophysiological parameters were analyzed. After the administration of dl-sotalol, the cycle length of the sinus rate, the QT interval, and the effective refractory period were prolonged significantly. In 11 patients, VT was not induced (responders) to the end of the entire protocol of induction. In another 10 patients, dl-sotalol proved a failure and a slower VT with a similar width of zone of entrainment remained inducible. The cycle length of VT and the width of the zone of entrainment did not differ between the responders and non-responders to dl-sotalol: 300±72 vs. 275±21 msec and 57±27 vs. 50±16 msec, respectively. Conclusions: The VT induction was prevented by dl-sotalol in 52%, but the cycle length, the zone of entrainment of VT, and other variables were not different between the responders and non-responders to dl-sotalol. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 51, 号 4, p. 133-140, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
