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p21^<WAF1/CIP1> and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation
http://hdl.handle.net/10191/1914
http://hdl.handle.net/10191/19148386860c-cbc2-480f-bfba-3af1fc037c2a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267694.pdf (6.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | p21^<WAF1/CIP1> and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation | |||||
| タイトル | ||||||
| タイトル | p21^<WAF1/CIP1> and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | serrated adenoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p21 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ki-67 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell maturation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell proliferation | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Komori, Koji
× Komori, Koji× Ajioka, Yoichi× Watanabe, Hidenobu× Oda, Koji× Nimura, Yuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The immunohistochemical expression of p21^<WAF1/CIP1> and Ki-67 of serrated adenoma (SA) (n=19) of the colorectum was evaluated in order to elucidate its cell differentiation/maturation status and its relationship with cell proliferation. This was then compared with those of a hyperplastic polyp (HP) (n=18), traditional tubular adenoma (TA) (n=21), and normal colonic mucosa (n=11). Longitudinally sectioned hemicrypts were selected from each sample, and the percentage of the p21^<WAF1/CIP1> (+) portion and the proliferative zone (PZ) per entire hemicrypt length were determined. In SA, although the topographic regulation of cell differentiation/maturation and proliferation was maintained, the percentage of PZ (26.5±1.8%) decreased and that of the p21^<WAF1/CIP1> (+) portion (61.4±2.1%) increased compared with those of normal colonic mucosa (31.8±1.3% and 30.6±1.4%) (p<0.05, respectively), indicating that the cell kinetic balance of SA was inclined toward cell differentiation/maturation. A similar cell kinetic imbalance was seen in HP, whereas the cell kinetic balance was inclined toward cell proliferation in TA. These findings suggest that, unlike TA, SA is a disorder of cell differentiation/maturation rather than cell proliferation, and the elongation of the cell life span and the subsequent reduction of exfoliation, which are the known fundamental cell kinetics of HP, may contribute to its neoplastic growth. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 51, 号 4, p. 117-124, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Komori, Koji, Ajioka, Yoichi, Watanabe, Hidenobu, Oda, Koji, Nimura, Yuji, 2003, p21^<WAF1/CIP1> and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation: Niigata University School of Medicine, 117–124 p.
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