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Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion
http://hdl.handle.net/10191/1889
http://hdl.handle.net/10191/18891cd4528a-c908-4f86-ac44-91a7b2693870
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267745.pdf (1.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion | |||||
| タイトル | ||||||
| タイトル | Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | unexplained recurrent abortion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TH1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TH2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | blocking antibodies | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
MITSUI, Takuya
× MITSUI, Takuya× TAKAKUWA, Koichi× ISHII, Keisuke× TAMURA, Masaki× TANAKA, Kenichi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: This study elucidated the correlation among blocking antibodies as detected by means of a mixed lymphocyte culture reaction (MLR) between spouses (MLR-BAbs), type I helper T cells (TH1), and type II helper T cells (TH2) in patients with unexplained recurrent abortions. Study design: Forty-five patients with unexplained recurrent abortions were chosen as a study population. Cells with TH1 and TH2 were determined by detecting intracellular interferon (IFN) -gamma and interleukin-4 (IL-4) production. The percentage of TH1 cells, TH2 cells, and the TH1/TH2 ratio were compared between MLR-BAbs-positive group and -negative group. The correlation between MLR-blocking effect and TH1 cells, TH2 cells, and TH1/TH2 ratio were also analyzed. Results and conclusion: Of 45 patients, 12 were positive for MLR-BAbs (MLR-BAbs positive group) and 33 were negative for MLR-BAbs (MLR-BAbs negative group). Although the percentage of TH2 cells was not significantly different between the two groups, the percentages of TH1 cells and the TH1/TH2 ratio were significantly higher in patients with negative MLR-BAbs compared with those positive for MLR-BAbs. Moreover, the MLR-blocking effect showed a significant negative correlation with the TH1/TH2 ratio in the patient population. Thus, it is suggested that the BAbs evaluated by MLR between spouses might reflect the TH1/TH2 balance in patients with unexplained recurrent abortion. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 1, p. 29-36, 発行日 2004-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
