{"_buckets": {"deposit": "a2c696cf-c4e2-4565-a793-0d103a5d8a12"}, "_deposit": {"id": "6255", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6255"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006255", "sets": ["456", "589"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "36", "bibliographicPageStart": "29", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: This study elucidated the correlation among blocking antibodies as detected by means of a mixed lymphocyte culture reaction (MLR) between spouses (MLR-BAbs), type I helper T cells (TH1), and type II helper T cells (TH2) in patients with unexplained recurrent abortions. Study design: Forty-five patients with unexplained recurrent abortions were chosen as a study population. Cells with TH1 and TH2 were determined by detecting intracellular interferon (IFN) -gamma and interleukin-4 (IL-4) production. The percentage of TH1 cells, TH2 cells, and the TH1/TH2 ratio were compared between MLR-BAbs-positive group and -negative group. The correlation between MLR-blocking effect and TH1 cells, TH2 cells, and TH1/TH2 ratio were also analyzed. Results and conclusion: Of 45 patients, 12 were positive for MLR-BAbs (MLR-BAbs positive group) and 33 were negative for MLR-BAbs (MLR-BAbs negative group). Although the percentage of TH2 cells was not significantly different between the two groups, the percentages of TH1 cells and the TH1/TH2 ratio were significantly higher in patients with negative MLR-BAbs compared with those positive for MLR-BAbs. Moreover, the MLR-blocking effect showed a significant negative correlation with the TH1/TH2 ratio in the patient population. Thus, it is suggested that the BAbs evaluated by MLR between spouses might reflect the TH1/TH2 balance in patients with unexplained recurrent abortion.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MITSUI, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "51943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKAKUWA, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "51944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHII, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "51945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAMURA, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "51946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANAKA, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "51947", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004267745.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "KJ00004267745.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6255/files/KJ00004267745.pdf"}, "version_id": "5d0be5d2-9a6b-47c4-ac0f-0844feef3611"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "unexplained recurrent abortion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TH1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TH2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blocking antibodies", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion"}, {"subitem_title": "Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "589"], "permalink_uri": "http://hdl.handle.net/10191/1889", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6255", "relation": {}, "relation_version_is_last": true, "title": ["Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion"], "weko_shared_id": null}