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The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters
http://hdl.handle.net/10191/1864
http://hdl.handle.net/10191/18649d0ce3ce-ec5b-4407-b14a-f0c4af7a3bf0
名前 / ファイル | ライセンス | アクション |
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KJ00004271970.pdf (3.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ibuprofen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | total body irradiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid peroxidation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | superoxide dismutase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | catalase | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
DOKMECI, Dikmen
× DOKMECI, Dikmen× AKPOLAT, Meryem× AYDOGDU, Nurettin× UZAL, Cem× TURAN, Nesrin F. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radiation therapy plays an important role in curative and palliative treatments of malignant diseases. Because of the lipid component in the membrane, lipid peroxidation has been reported to be particularly susceptible to radiation damage. However, lipid peroxidation is reversed by cellular defense mechanisms, and the use of various antioxidants involved in these mechanisms have recently been suggested to be beneficial. It is known that ibuprofen has antioxidative and/or free radical scavenging activities. Our purpose is to examine the antioxidant capacity of ibuprofen in hamsters undergoing total body irradiation (TBI). Ibuprofen was given by gavage at dose of 10mg/kg for 15 consecutive days. After this period, animals were exposed to TBI ^<60>Co gamma irradiation with a single dose of 8 Gy. After 24h radiation exposure, the hamsters were killed and samples were taken from blood. Plasma thiobarbituric acid reactive substances (TBARS) increased significantly after radiation exposure, and ibuprofen diminished the amounts of TBARS. Significant protection of the radiation-induced changes in the activities of superoxide dismutase (SOD) and catalase was also recorded in the blood of ibuprofen-treated and -irradiated hamsters. These results suggest that ibuprofen with its antioxidant capacity could play a modulatory role against cellular damage effected by free radicals induced by TBI. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 2, p. 67-72, 発行日 2004-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |