ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "64f32310-5ca6-43fe-848f-3d0fe88400e6"}, "_deposit": {"id": "6250", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6250"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006250", "sets": ["456", "588"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "72", "bibliographicPageStart": "67", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Radiation therapy plays an important role in curative and palliative treatments of malignant diseases. Because of the lipid component in the membrane, lipid peroxidation has been reported to be particularly susceptible to radiation damage. However, lipid peroxidation is reversed by cellular defense mechanisms, and the use of various antioxidants involved in these mechanisms have recently been suggested to be beneficial. It is known that ibuprofen has antioxidative and/or free radical scavenging activities. Our purpose is to examine the antioxidant capacity of ibuprofen in hamsters undergoing total body irradiation (TBI). Ibuprofen was given by gavage at dose of 10mg/kg for 15 consecutive days. After this period, animals were exposed to TBI ^\u003c60\u003eCo gamma irradiation with a single dose of 8 Gy. After 24h radiation exposure, the hamsters were killed and samples were taken from blood. Plasma thiobarbituric acid reactive substances (TBARS) increased significantly after radiation exposure, and ibuprofen diminished the amounts of TBARS. Significant protection of the radiation-induced changes in the activities of superoxide dismutase (SOD) and catalase was also recorded in the blood of ibuprofen-treated and -irradiated hamsters. These results suggest that ibuprofen with its antioxidant capacity could play a modulatory role against cellular damage effected by free radicals induced by TBI.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "DOKMECI, Dikmen"}], "nameIdentifiers": [{"nameIdentifier": "51919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AKPOLAT, Meryem"}], "nameIdentifiers": [{"nameIdentifier": "51920", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AYDOGDU, Nurettin"}], "nameIdentifiers": [{"nameIdentifier": "51921", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UZAL, Cem"}], "nameIdentifiers": [{"nameIdentifier": "51922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TURAN, Nesrin F."}], "nameIdentifiers": [{"nameIdentifier": "51923", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004271970.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "KJ00004271970.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6250/files/KJ00004271970.pdf"}, "version_id": "e4009441-543f-47d0-b675-1109c1866acb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ibuprofen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "total body irradiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxidative injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lipid peroxidation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "superoxide dismutase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "catalase", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters"}, {"subitem_title": "The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "588"], "permalink_uri": "http://hdl.handle.net/10191/1864", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6250", "relation": {}, "relation_version_is_last": true, "title": ["The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.52 No.2

The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters

http://hdl.handle.net/10191/1864
http://hdl.handle.net/10191/1864
9d0ce3ce-ec5b-4407-b14a-f0c4af7a3bf0
名前 / ファイル ライセンス アクション
KJ00004271970.pdf KJ00004271970.pdf (3.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters
タイトル
言語 en
タイトル The Modifying Effect of Ibuprofen on Total Body Irradiation-induced Elevation of Oxidative Reactions in Male Hamsters
言語
言語 eng
キーワード
主題Scheme Other
主題 ibuprofen
キーワード
主題Scheme Other
主題 total body irradiation
キーワード
主題Scheme Other
主題 oxidative injury
キーワード
主題Scheme Other
主題 lipid peroxidation
キーワード
主題Scheme Other
主題 superoxide dismutase
キーワード
主題Scheme Other
主題 catalase
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 DOKMECI, Dikmen

× DOKMECI, Dikmen

WEKO 51919

DOKMECI, Dikmen

Search repository
AKPOLAT, Meryem

× AKPOLAT, Meryem

WEKO 51920

AKPOLAT, Meryem

Search repository
AYDOGDU, Nurettin

× AYDOGDU, Nurettin

WEKO 51921

AYDOGDU, Nurettin

Search repository
UZAL, Cem

× UZAL, Cem

WEKO 51922

UZAL, Cem

Search repository
TURAN, Nesrin F.

× TURAN, Nesrin F.

WEKO 51923

TURAN, Nesrin F.

Search repository
抄録
内容記述タイプ Abstract
内容記述 Radiation therapy plays an important role in curative and palliative treatments of malignant diseases. Because of the lipid component in the membrane, lipid peroxidation has been reported to be particularly susceptible to radiation damage. However, lipid peroxidation is reversed by cellular defense mechanisms, and the use of various antioxidants involved in these mechanisms have recently been suggested to be beneficial. It is known that ibuprofen has antioxidative and/or free radical scavenging activities. Our purpose is to examine the antioxidant capacity of ibuprofen in hamsters undergoing total body irradiation (TBI). Ibuprofen was given by gavage at dose of 10mg/kg for 15 consecutive days. After this period, animals were exposed to TBI ^<60>Co gamma irradiation with a single dose of 8 Gy. After 24h radiation exposure, the hamsters were killed and samples were taken from blood. Plasma thiobarbituric acid reactive substances (TBARS) increased significantly after radiation exposure, and ibuprofen diminished the amounts of TBARS. Significant protection of the radiation-induced changes in the activities of superoxide dismutase (SOD) and catalase was also recorded in the blood of ibuprofen-treated and -irradiated hamsters. These results suggest that ibuprofen with its antioxidant capacity could play a modulatory role against cellular damage effected by free radicals induced by TBI.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 52, 号 2, p. 67-72, 発行日 2004-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:42:53.008430
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3