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Definition and Histogenesis of Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas
http://hdl.handle.net/10191/1826
http://hdl.handle.net/10191/18265113d724-045e-4f5e-b5df-117af20c2f19
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004271969.pdf (7.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Definition and Histogenesis of Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas | |||||
| タイトル | ||||||
| タイトル | Definition and Histogenesis of Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pancreatic tumor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mucinous cystic neoplasm | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intraductal papillary mucinous neoplasm | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ovarian-type stroma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | estrogen receptor | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Kurosaki, Ryo
× Kurosaki, Ryo× Ajioka, Yoichi× Shirai, Yoshio× Watanabe, Hidenobu× Emura, Iwao× Ohta, Tamaki× Tsuchiya, Yoshiaki× Yamano, Miki× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: The present study aimed to clarify the definitions and histogenesis of ovarian-type stroma (OTS) in mucinous cystic neoplasms (MCNs) of the pancreas. Methods: Expression and density of cells positive for estrogen receptor (ER) and progesterone receptor (PR) were immunohistochemically studied in 16 MCNs (6 adenomas, 10 carcinomas), 22 intraductal papillary mucinous neoplasms (IPMNs), 10 common-type invasive ductal carcinomas (IDCs) and 24 non-neoplastic pancreatic tissues. Results: OTS comprised densely packed spindleshaped cells with round or elongated nuclei. Stromal cells were diffusely positive for ER and PR in all 16 MCNs. OTS-like stromal cells in IPMNs and IDCs were negative or only sporadically positive for ER or PR in all cases. In non-neoplastic pancreatic tissue, ER- and PR-reactive stromal cells were scattered sporadically irrespective of site in the pancreas (head, body or tail) or sex. Conclusions: OTS is an absolute marker for diagnosis of pancreatic MCNs and should be confirmed as ER- and PR-reactive on immunostaining in addition to findings from sections stained using hematoxylin-eosin. ER- and PR-reactive stromal cells may become hypersensitive to female sex hormone stimulation and start to proliferate and form OTS in the pancreas. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 2, p. 57-65, 発行日 2004-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
