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C-terminus SDEL of BMZ Olfactomedin-related Protein is a Golgi Retention Signal in Glomerular Podocytes
http://hdl.handle.net/10191/1876
http://hdl.handle.net/10191/187617e68dd1-ce9e-4b19-b380-8efec9b944cb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004271968.pdf (4.9 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | C-terminus SDEL of BMZ Olfactomedin-related Protein is a Golgi Retention Signal in Glomerular Podocytes | |||||
| タイトル | ||||||
| タイトル | C-terminus SDEL of BMZ Olfactomedin-related Protein is a Golgi Retention Signal in Glomerular Podocytes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glomerulus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | golgi apparatus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kidney | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | podocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | olfactomedin | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
KOBAYASHI, Hideyuki
× KOBAYASHI, Hideyuki× KONDO, Daisuke× NAMETA, Masaaki× DANIELSON, Patria E.× FUJINAKA, Hidehiko× QU, Zhenyun× ZOU, Jun× LI, Huiping× YOSHIDA, Yutaka× YAOITA, Eishin× SUTCLIFFE, J. Gregor× GEJYO, Fumitake× YAMAMOTO, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Olfactomedin-related proteins are members of a gene family with conserved C-terminus motifs. We isolated one member of this gene family, BMZ olfactomedin-related protein, from rat glomerulus during searching for glomerulus-specific genes. The BMZ olfactomedin-related protein was uniquely immunolocalized in podocytes in the kidney. By double label immunofluorescence microscopy and immunoelectron microscopy, localization of the protein was demonstrated at the Golgi apparatus in the podocyte. To examine a role of C-terminus amino acid sequence, SDEL, of this protein in the retention at the Golgi apparatus, BMZ olfactomedin-related protein with wild-type SDEL sequence or mutated KDEL or PEET sequence at the C-terminus was expressed in CHO cells by transfection with plasmid expression vectors. BMZ olfactomedin-related protein with SDEL C-terminus was accumulated to the perinuclear region and was co-localized with giantin (a marker of Golgi apparatus) in these cells. On the other hand, BMZ olfactomedin-related protein with KDEL or PEET at the C-terminus distributed diffusely in the cytoplasm of CHO cells in a close association with giantin. These findings suggested that the C-terminus SDEL sequence of BMZ olfactomedin-related protein is involved in retention of this protein at the Golgi apparatus of podocytes. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 2, p. 51-56, 発行日 2004-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
