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BAFF Is Expressed on Human Platelets and Upregulated by Activation
http://hdl.handle.net/10191/1924
http://hdl.handle.net/10191/19248b3395a2-5bee-4804-b83c-a8b7f1d48321
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161686.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | BAFF Is Expressed on Human Platelets and Upregulated by Activation | |||||
| タイトル | ||||||
| タイトル | BAFF Is Expressed on Human Platelets and Upregulated by Activation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | B-cell-activating factor belonging to the TNF family (BAFF) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | platelets | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | activation | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
MOMOI, Akihito
× MOMOI, Akihito× FUSE, Ichiro× TSUKADA, Nobuhiro× AIZAWA, Yoshifusa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Activated platelets express CD154, a member of the tumor necrosis factor (TNF) family that plays an important role in the activation of B cells and other antigen-presenting cells (APC). This may facilitate the initiation of immune responses at sites of thrombosis in response to injury. We examined platelets and megakaryocytic cell lines for the expression of another member of the TNF family, B-cell-activating factor belonging to the TNF family (BAFF) (otherwise known as Blys, TALL-1, THANK, TNFSF13B, or zTNF4). The surface expression of BAFF can be detected by flow cytometry on resting platelets from healthy individuals and patients with collagen diseases and hepatitis C virus (HCV) carrier/hepatitis/liver chirrhosis. BAFF can be expressed by activation with thrombin, even if it is not expressed in the resting state. Using sensitive reverse transcriptase polymerase chain reaction (RT-PCR), we detected BAFF mRNA in megakaryocytic cell lines but not in mature platelets isolated from healthy donors. Immunoblot analysis revealed, however, that both megakaryocytic cell lines and mature platelets contained protein of the appropriate size of the membrane-bound form of BAFF that reacted specifically with anti-BAFF antibodies. Our studies reveal that platelets express BAFF, which may imply possible roles of physiologic or pathologic platelet activation at local sites. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 4, p. 117-126, 発行日 2004-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
MOMOI, Akihito, FUSE, Ichiro, TSUKADA, Nobuhiro, AIZAWA, Yoshifusa, 2004, BAFF Is Expressed on Human Platelets and Upregulated by Activation: Niigata University School of Medicine, 117–126 p.
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