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Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract
http://hdl.handle.net/10191/1869
http://hdl.handle.net/10191/1869ac986a79-ad0b-4e3b-9b27-5631c1111623
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161701.pdf (2.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract | |||||
| タイトル | ||||||
| タイトル | Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aquaporin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bladder | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ureter | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | urethra | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | urothelium | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
QU, Zhenyun
× QU, Zhenyun× NISHIMOTO, Goro× ZOU, Jun× LI, Huiping× YOSHIDA, Yutaka× YAOITA, Eishin× YAMAMOTO, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Water is filtered from the circulation into urine in the glomerulus and is reabsorbed mostly in the proximal tubules and descending loop of Henle and partially in the collecting ducts through several types of water channels, the aquaporin (AQP1, AQP2, AQP3, AQP4 and AQP7). Since AQP2, AQP3, and AQP4 have been identified in the collecting ducts, which originate from urinary buds during the development of the kidney as the ureter, bladder, and urethra, it is presumable for these aquaporins to locate in the urothelium covering the luminal surface of these tissues. However, it has been suggested that the urothelium is impermeable to water and/or solutes. Hence, we examined the expression and localization of aquaporin family members (AQP1, AQP2, AQP3 and AQP4) in the urinary tract in rats. As a consequence, the expression of AQP1 and AQP3 mRNA were demonstrated in the ureter, bladder, and urethra by ribonuclease protection assay. Western blotting showed distinct bands for both AQP1 and AQP3 in the ureter, bladder, and urethra. By immunohistochemistry, AQP1 was localized in the endothelial cells of blood vessels and AQP3 in intermediate and basal cell layers of the urothelium in the ureter, bladder and urethra. No AQP2 or AQP4 mRNA expression or immunolocalization of AQP2 and AQP4 were detected in these tissues. AQP2 expression was enhanced hi the kidney after dehydration; however, the expression was unchanged in the ureter, bladder, and urethra. The current findings suggest that water crosses the urothelium by utilizing AQP3 water channels (transcellular pathway) in the ureter, bladder, and urethra, but the expression of AQP3 is not regulated by a dehydrated condition. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 53, 号 1, p. 13-19, 発行日 2005-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
