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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.53 No.1

Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract

http://hdl.handle.net/10191/1869
http://hdl.handle.net/10191/1869
ac986a79-ad0b-4e3b-9b27-5631c1111623
名前 / ファイル ライセンス アクション
KJ00004161701.pdf KJ00004161701.pdf (2.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract
タイトル
言語 en
タイトル Expression and Localization of the Water Channel, Aquaporin, in the Rat Urinary Tract
言語
言語 eng
キーワード
主題Scheme Other
主題 aquaporin
キーワード
主題Scheme Other
主題 bladder
キーワード
主題Scheme Other
主題 ureter
キーワード
主題Scheme Other
主題 urethra
キーワード
主題Scheme Other
主題 urothelium
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 QU, Zhenyun

× QU, Zhenyun

WEKO 51832

QU, Zhenyun

Search repository
NISHIMOTO, Goro

× NISHIMOTO, Goro

WEKO 51833

NISHIMOTO, Goro

Search repository
ZOU, Jun

× ZOU, Jun

WEKO 51834

ZOU, Jun

Search repository
LI, Huiping

× LI, Huiping

WEKO 51835

LI, Huiping

Search repository
YOSHIDA, Yutaka

× YOSHIDA, Yutaka

WEKO 51836

YOSHIDA, Yutaka

Search repository
YAOITA, Eishin

× YAOITA, Eishin

WEKO 51837

YAOITA, Eishin

Search repository
YAMAMOTO, Tadashi

× YAMAMOTO, Tadashi

WEKO 51838

YAMAMOTO, Tadashi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Water is filtered from the circulation into urine in the glomerulus and is reabsorbed mostly in the proximal tubules and descending loop of Henle and partially in the collecting ducts through several types of water channels, the aquaporin (AQP1, AQP2, AQP3, AQP4 and AQP7). Since AQP2, AQP3, and AQP4 have been identified in the collecting ducts, which originate from urinary buds during the development of the kidney as the ureter, bladder, and urethra, it is presumable for these aquaporins to locate in the urothelium covering the luminal surface of these tissues. However, it has been suggested that the urothelium is impermeable to water and/or solutes. Hence, we examined the expression and localization of aquaporin family members (AQP1, AQP2, AQP3 and AQP4) in the urinary tract in rats. As a consequence, the expression of AQP1 and AQP3 mRNA were demonstrated in the ureter, bladder, and urethra by ribonuclease protection assay. Western blotting showed distinct bands for both AQP1 and AQP3 in the ureter, bladder, and urethra. By immunohistochemistry, AQP1 was localized in the endothelial cells of blood vessels and AQP3 in intermediate and basal cell layers of the urothelium in the ureter, bladder and urethra. No AQP2 or AQP4 mRNA expression or immunolocalization of AQP2 and AQP4 were detected in these tissues. AQP2 expression was enhanced hi the kidney after dehydration; however, the expression was unchanged in the ureter, bladder, and urethra. The current findings suggest that water crosses the urothelium by utilizing AQP3 water channels (transcellular pathway) in the ureter, bladder, and urethra, but the expression of AQP3 is not regulated by a dehydrated condition.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 53, 号 1, p. 13-19, 発行日 2005-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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