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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.53 No.4

Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats

http://hdl.handle.net/10191/1832
http://hdl.handle.net/10191/1832
bca85124-3873-42bc-8c63-4b800b24bfa3
名前 / ファイル ライセンス アクション
KJ00004355706.pdf KJ00004355706.pdf (5.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats
タイトル
タイトル Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 low protein diet
キーワード
主題Scheme Other
主題 high protein diet
キーワード
主題Scheme Other
主題 irreversible mesangioproliferative glomerulonephritis
キーワード
主題Scheme Other
主題 proteinuria
キーワード
主題Scheme Other
主題 collagen type-I
キーワード
主題Scheme Other
主題 TGF-β
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 FUJIOKA, Yumiko

× FUJIOKA, Yumiko

WEKO 51744

FUJIOKA, Yumiko

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SUZUKI, Koichi

× SUZUKI, Koichi

WEKO 51745

SUZUKI, Koichi

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NAKATSUE, Takeshi

× NAKATSUE, Takeshi

WEKO 51746

NAKATSUE, Takeshi

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HAN, Gi Dong

× HAN, Gi Dong

WEKO 51747

HAN, Gi Dong

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KOIKE, Hiroko

× KOIKE, Hiroko

WEKO 51748

KOIKE, Hiroko

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KAWACHI, Hiroshi

× KAWACHI, Hiroshi

WEKO 51749

KAWACHI, Hiroshi

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SHIMIZU, Fujio

× SHIMIZU, Fujio

WEKO 51750

SHIMIZU, Fujio

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抄録
内容記述タイプ Abstract
内容記述 We aimed to investigate the effects of early intervention in reducing dietary protein intake on chronic progressive GN (glomerulonephritis) by using an irreversible mesangioproliferative GN model. An irreversible mesangioproliferative GN model was induced by two injections of monoclonal anti Thy-1 antibody 1-22-3 two weeks apart. In Experiment 1, 10 rats were divided into a low protein diet (LPD: 6.4% protein) group and a normal protein diet (NPD: 25.4% protein) group. In Experiment 2, another 10 rats were divided into a high protein diet (HPD: 52.5% protein) group and an NPD group. After 10 weeks of administering an experimental diet, the rats were sacrificed to undergo blood biochemistry, light microscopy, and immunofluorescence analyses of the kidneys as well as a glomerular mRNA study. In the LPD group, urinary protein excretion and the expression of collagen type-I mRNA and protein all significantly decreased in comparison with the NPD group. In addition, the mesangial matrix expansion and the glomerular expression of α-smooth muscle actin (α-SMA) and transforming growth-factor-β (TGF-β) mRNA in the LPD group were lower than those in NPD group. However, in the HPD group, both TGF-β and collagen type-I glomerular mRNA expression were higher. The LPD therapy from the early stages of renal dysfunction can be considered effective in preventing further progression of the disease to chronic renal failure.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 53, 号 4, p. 95-107, 発行日 2005-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
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