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Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats
http://hdl.handle.net/10191/1832
http://hdl.handle.net/10191/1832bca85124-3873-42bc-8c63-4b800b24bfa3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004355706.pdf (5.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats | |||||
| タイトル | ||||||
| タイトル | Early Intervention in Reducing Dietary Protein Intake Ameliorates Irreversible Mesangioproliferative Glomerulonephritis in Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | low protein diet | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | high protein diet | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | irreversible mesangioproliferative glomerulonephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | proteinuria | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | collagen type-I | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TGF-β | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
FUJIOKA, Yumiko
× FUJIOKA, Yumiko× SUZUKI, Koichi× NAKATSUE, Takeshi× HAN, Gi Dong× KOIKE, Hiroko× KAWACHI, Hiroshi× SHIMIZU, Fujio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We aimed to investigate the effects of early intervention in reducing dietary protein intake on chronic progressive GN (glomerulonephritis) by using an irreversible mesangioproliferative GN model. An irreversible mesangioproliferative GN model was induced by two injections of monoclonal anti Thy-1 antibody 1-22-3 two weeks apart. In Experiment 1, 10 rats were divided into a low protein diet (LPD: 6.4% protein) group and a normal protein diet (NPD: 25.4% protein) group. In Experiment 2, another 10 rats were divided into a high protein diet (HPD: 52.5% protein) group and an NPD group. After 10 weeks of administering an experimental diet, the rats were sacrificed to undergo blood biochemistry, light microscopy, and immunofluorescence analyses of the kidneys as well as a glomerular mRNA study. In the LPD group, urinary protein excretion and the expression of collagen type-I mRNA and protein all significantly decreased in comparison with the NPD group. In addition, the mesangial matrix expansion and the glomerular expression of α-smooth muscle actin (α-SMA) and transforming growth-factor-β (TGF-β) mRNA in the LPD group were lower than those in NPD group. However, in the HPD group, both TGF-β and collagen type-I glomerular mRNA expression were higher. The LPD therapy from the early stages of renal dysfunction can be considered effective in preventing further progression of the disease to chronic renal failure. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 53, 号 4, p. 95-107, 発行日 2005-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
