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Caspase-3 Activation and Apoptosis Induction in THP-1 Human Monocytic Cells by Clinical and Environmental Isolates of Vibrio vulnificus
http://hdl.handle.net/10191/5232
http://hdl.handle.net/10191/523267bf7708-8efd-4472-8d16-277227f1d1f9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
17_0005.pdf (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Caspase-3 Activation and Apoptosis Induction in THP-1 Human Monocytic Cells by Clinical and Environmental Isolates of Vibrio vulnificus | |||||
| タイトル | ||||||
| タイトル | Caspase-3 Activation and Apoptosis Induction in THP-1 Human Monocytic Cells by Clinical and Environmental Isolates of Vibrio vulnificus | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Vibrio vulnificus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | caspase-3 activation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apoptosis induction | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Iwakura, Nobuhiro
× Iwakura, Nobuhiro× Kojio, Seiichi× Shibuya, Michiko× Ozaki, Kyoko× Takano, Misao× Nakayama, Teruko× Nakagawa, Saori× Okubo, Takeshi× Taneike, Ikue× Yamamoto, Tatsuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vibrio vulnificus is an estuarine bacterium that is severely invasive and fatal for susceptible persons. The pathogenesis of V. vulnificus has not yet been clarified. This study showed that clinical strains as well as freshly-isolated environmental strains-but not storedenvironmental strains-of V. vulnificus markedly activated caspase proteolytic activities, such as caspase-3, -2, and -6 of THP-1 human monocytic cells. Caspase-3 activation was correlated with internucleosomal DNA fragmentation and chromation condensation of the cells. V. vulnificus activities responsible for the caspase-3 activation were present in the culture filtrates and were temperature-resistant. Consistent with the caspase-3 activation levels, the clinical strains and freshly-isolated environmental strains exhibited strong lethality in mice as compared with storedenvironmental strains. These data suggest that the caspase-3 activation factor could be a major factor in virulence produced by V. vulnificus. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 54, 号 2, p. 43-50, 発行日 2006-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
