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Relationship between Single Nucleotide Polymorphisms in CYP1A1 and CYP1B1 Genes and Bone Mineral Density in Postmenopausal Japanese Women on Hormone Replacement Therapy
http://hdl.handle.net/10191/5241
http://hdl.handle.net/10191/52413d3450ac-970f-4d51-83df-c826509b33fa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
17_0014.pdf (360.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Relationship between Single Nucleotide Polymorphisms in CYP1A1 and CYP1B1 Genes and Bone Mineral Density in Postmenopausal Japanese Women on Hormone Replacement Therapy | |||||
| タイトル | ||||||
| タイトル | Relationship between Single Nucleotide Polymorphisms in CYP1A1 and CYP1B1 Genes and Bone Mineral Density in Postmenopausal Japanese Women on Hormone Replacement Therapy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone mineral density (BMD) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CYP1A1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CYP1B1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hormone replacement therapy (HRT) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | single nucleotide polymorphism (SNP) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Quan, Jinhua
× Quan, Jinhua |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The objective of this study was to evaluate the relationships between single nucleotide polymorphism of estrogen metabolizing genes and lumbar bone mineral density (BMD) and to determine the effects of hormone replacement therapy (HRT). Weconducted a case study at the Niigata University Medical and Dental Hospital. The patients were 124 Japanese women diagnosed with osteopenia or osteoporosis and taking HRT for 12 months. Seven single nucleotide polymorphism (SNPs) in the cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) genes were characterized by a single nucleotide primer extension assay. The lumbar bone mineral density (BMD) were measured before and following 12 months of HRT. The genotyping of the 124 postmenopausal Japanese womenrevealed three out of seven SNPs to be quite common, with the minor allele frequency being at least 20%. A SNP in exon3 of CYP1B1 (L432V) was found to be significantly associated with the effect of HRT on BMD.In patients with the GG genotype of L432V, the responses to HRT in BMD markedly decreased. Wedemonstrated that a SNP in the CYP1B1 gene is associated with the magnitude of BMDin response to HRT.These results suggest that L432V polymorphism in the CYP1B1 gene could be used to predict the effect ofHRT on lumbar BMD. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 1, p. 17-22, 発行日 2007-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
