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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.55 No.2

Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis

http://hdl.handle.net/10191/5243
http://hdl.handle.net/10191/5243
4fd9ac9e-5189-4629-a5bb-242d6efbe42f
名前 / ファイル ライセンス アクション
17_0016.pdf 17_0016.pdf (970.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-04-08
タイトル
タイトル Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis
タイトル
言語 en
タイトル Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis
言語
言語 eng
キーワード
主題Scheme Other
主題 intrahepatic cholangiocarcinoma
キーワード
主題Scheme Other
主題 microsatellite instability
キーワード
主題Scheme Other
主題 K-ras
キーワード
主題Scheme Other
主題 β-catenin
キーワード
主題Scheme Other
主題 p53
キーワード
主題Scheme Other
主題 hepatolithiasis
キーワード
主題Scheme Other
主題 carcinogenesis
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Shimizu, Hiroki

× Shimizu, Hiroki

WEKO 51590

Shimizu, Hiroki

Search repository
Ajioka, Yoichi

× Ajioka, Yoichi

WEKO 51591

Ajioka, Yoichi

Search repository
Akagawa, Takashi

× Akagawa, Takashi

WEKO 51592

Akagawa, Takashi

Search repository
Oda, Koji

× Oda, Koji

WEKO 51593

Oda, Koji

Search repository
Nimura, Yuji

× Nimura, Yuji

WEKO 51594

Nimura, Yuji

Search repository
Chen, Miin-Fu

× Chen, Miin-Fu

WEKO 51595

Chen, Miin-Fu

Search repository
Jan, Yi-Yin

× Jan, Yi-Yin

WEKO 51596

Jan, Yi-Yin

Search repository
Huang, Shiu-Feng

× Huang, Shiu-Feng

WEKO 51597

Huang, Shiu-Feng

Search repository
Watanabe, Gen

× Watanabe, Gen

WEKO 51598

Watanabe, Gen

Search repository
Nishikura, Ken

× Nishikura, Ken

WEKO 51599

Nishikura, Ken

Search repository
Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 51600

Hatakeyama, Katsuyoshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 To determine whether genetic alterations in intrahepatic cholangiocarcinoma (ICC) differ by the association of chronic inflammation induced by hepatolithiasis, we analyzed p53 protein overexpression, aberrant β-catenin nuclear expression, microsatellite instability (MSI) status, and K-ras codon 12 mutation in 20 cases with ICC (13 with hepatolithiasis and seven without hepatolithiasis). Positive frequencies of each variable for ICC with and without hepatolithiasis were: p53 overexpression, 38% vs 14%; aberrant β-catenin nuclear expression, 23% vs 0%; MSI-high, 0% vs 0%; MSI-low, 13% vs 17%; and K-ras mutation, 31% vs 14%. Aberrant β-catenin nuclear expression showed a sporadic pattern in all cases. There were no significant differences in any of the frequencies between ICCs with and without hepatolithiasis. These results suggest that genetic alterations in ICC do not differ according to the presence of chronic inflammation by hepatolithiasis. However, these results may be partly attributable to the small sample number of ICC cases with hepatolithiasis in the present study. Additional studies of ICC with hepatolithiasis and further investigations are required to obtain definitive conclusions. With regard to ICC without hepatolithiasis, the present results imply that alterations of p53 and K-ras may play crucial roles in the carcinogenesis of a subset (30 to 40%) of ICC, and adenomatous polyposis coli (APC) alterations represented by aberrant β-catenin nuclear expression and defects in the DNA mismatch repair system represented by MSI-high may not contribute to ICC carcinogenesis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 55, 号 2, p. 35-43, 発行日 2007-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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