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Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis
http://hdl.handle.net/10191/5243
http://hdl.handle.net/10191/52434fd9ac9e-5189-4629-a5bb-242d6efbe42f
名前 / ファイル | ライセンス | アクション |
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17_0016.pdf (970.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-08 | |||||
タイトル | ||||||
タイトル | Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis | |||||
タイトル | ||||||
タイトル | Analyses of p53 Overexpression, Aberrant β-Catenin Expression, Microsatellite Instability, and K-ras Mutation in Intrahepatic Cholangiocarcinoma with and without Hepatolithiasis | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intrahepatic cholangiocarcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microsatellite instability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | K-ras | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-catenin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatolithiasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carcinogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Shimizu, Hiroki
× Shimizu, Hiroki× Ajioka, Yoichi× Akagawa, Takashi× Oda, Koji× Nimura, Yuji× Chen, Miin-Fu× Jan, Yi-Yin× Huang, Shiu-Feng× Watanabe, Gen× Nishikura, Ken× Hatakeyama, Katsuyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine whether genetic alterations in intrahepatic cholangiocarcinoma (ICC) differ by the association of chronic inflammation induced by hepatolithiasis, we analyzed p53 protein overexpression, aberrant β-catenin nuclear expression, microsatellite instability (MSI) status, and K-ras codon 12 mutation in 20 cases with ICC (13 with hepatolithiasis and seven without hepatolithiasis). Positive frequencies of each variable for ICC with and without hepatolithiasis were: p53 overexpression, 38% vs 14%; aberrant β-catenin nuclear expression, 23% vs 0%; MSI-high, 0% vs 0%; MSI-low, 13% vs 17%; and K-ras mutation, 31% vs 14%. Aberrant β-catenin nuclear expression showed a sporadic pattern in all cases. There were no significant differences in any of the frequencies between ICCs with and without hepatolithiasis. These results suggest that genetic alterations in ICC do not differ according to the presence of chronic inflammation by hepatolithiasis. However, these results may be partly attributable to the small sample number of ICC cases with hepatolithiasis in the present study. Additional studies of ICC with hepatolithiasis and further investigations are required to obtain definitive conclusions. With regard to ICC without hepatolithiasis, the present results imply that alterations of p53 and K-ras may play crucial roles in the carcinogenesis of a subset (30 to 40%) of ICC, and adenomatous polyposis coli (APC) alterations represented by aberrant β-catenin nuclear expression and defects in the DNA mismatch repair system represented by MSI-high may not contribute to ICC carcinogenesis. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 2, p. 35-43, 発行日 2007-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |