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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.55 No.4

Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model

http://hdl.handle.net/10191/20707
http://hdl.handle.net/10191/20707
af3172a0-0969-4902-82e5-f0117cf38298
名前 / ファイル ライセンス アクション
110007138514.pdf 110007138514.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-21
タイトル
タイトル Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model
タイトル
言語 en
タイトル Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model
言語
言語 eng
キーワード
主題Scheme Other
主題 caerulein-induced pancreatitis model
キーワード
主題Scheme Other
主題 aquaporin 1
キーワード
主題Scheme Other
主題 aquaporin 8
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Koyama, Yu

× Koyama, Yu

WEKO 51555

Koyama, Yu

Search repository
Nishino, Hirokazu

× Nishino, Hirokazu

WEKO 51556

Nishino, Hirokazu

Search repository
Kurosaki, Isao

× Kurosaki, Isao

WEKO 51557

Kurosaki, Isao

Search repository
Iiai, Tsuneo

× Iiai, Tsuneo

WEKO 51558

Iiai, Tsuneo

Search repository
Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 51559

Hatakeyama, Katsuyoshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Aquaporins (AQPs) are a family of water channel proteins comprising 13 members, of which five (AQP 1, AQP 4, AQP 5, AQP 8 and AQP12) have been detected in the rat exocrine pancreas. However, the dynamics and role of AQPs in pancreatitis, which is characterized by interstitial edema and acinar cell injury, are unclear. This experimental study using a caerulein-induced pancreatitis model aimed to investigate the kinetics of AQPs in pancreatitis. Male Wistar rats received a caerulein infusion (10 μg/kg/h) for three h and then were sacrificed at three h and 72 h after the start of infusion. The expression of mRNA and protein for AQP1 and AQP8 were examined by quantitative reverse transcription polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry. In the control group, AQP1 was located in the pancreatic ductal cells and capillary endothelia, whereas AQP8 was positive only in the acinar cells. Macroscopically and microscopically, obvious pancreatitis was observed in the acute pancreatitis phase (three h group), while it disappeared in the recovery phase (72 h group). AQP1 expression in the pancreatic ductules decreased in both the three h and 72 h groups. AQP8 expression was depressed in the three h group when the acinar cell swelling was observed, while AQP8 expression was focally decreased in the 72 h group. These results suggest that the decrease in AQP1 and AQP8 show a latent injury in the ductal cells and acinar cells. They can be related to the mechanisms of edematous pancreatitis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 55, 号 4, p. 91-101, 発行日 2012-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 13458485
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN1046766X
権利
権利情報 本文データは学協会の許諾に基づきCiNiiから複製したものである
著者版フラグ
値 publisher
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