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Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model
http://hdl.handle.net/10191/20707
http://hdl.handle.net/10191/20707af3172a0-0969-4902-82e5-f0117cf38298
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
110007138514.pdf (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2013-01-21 | |||||
| タイトル | ||||||
| タイトル | Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model | |||||
| タイトル | ||||||
| タイトル | Dynamics of Aquaporin 1 and Aquaporin 8 in the Pancreas : An Experimental Study with a Caerulein-induced Pancreatitis Model | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | caerulein-induced pancreatitis model | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aquaporin 1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aquaporin 8 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Koyama, Yu
× Koyama, Yu× Nishino, Hirokazu× Kurosaki, Isao× Iiai, Tsuneo× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aquaporins (AQPs) are a family of water channel proteins comprising 13 members, of which five (AQP 1, AQP 4, AQP 5, AQP 8 and AQP12) have been detected in the rat exocrine pancreas. However, the dynamics and role of AQPs in pancreatitis, which is characterized by interstitial edema and acinar cell injury, are unclear. This experimental study using a caerulein-induced pancreatitis model aimed to investigate the kinetics of AQPs in pancreatitis. Male Wistar rats received a caerulein infusion (10 μg/kg/h) for three h and then were sacrificed at three h and 72 h after the start of infusion. The expression of mRNA and protein for AQP1 and AQP8 were examined by quantitative reverse transcription polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry. In the control group, AQP1 was located in the pancreatic ductal cells and capillary endothelia, whereas AQP8 was positive only in the acinar cells. Macroscopically and microscopically, obvious pancreatitis was observed in the acute pancreatitis phase (three h group), while it disappeared in the recovery phase (72 h group). AQP1 expression in the pancreatic ductules decreased in both the three h and 72 h groups. AQP8 expression was depressed in the three h group when the acinar cell swelling was observed, while AQP8 expression was focally decreased in the 72 h group. These results suggest that the decrease in AQP1 and AQP8 show a latent injury in the ductal cells and acinar cells. They can be related to the mechanisms of edematous pancreatitis. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 4, p. 91-101, 発行日 2012-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13458485 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN1046766X | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
