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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.56 No.1

Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy

http://hdl.handle.net/10191/19596
http://hdl.handle.net/10191/19596
bc70398d-08e9-4d9f-a7cf-90c66cee80d5
名前 / ファイル ライセンス アクション
110007138517.pdf 110007138517.pdf (632.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-09-28
タイトル
タイトル Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy
タイトル
言語 en
タイトル Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy
言語
言語 eng
キーワード
主題Scheme Other
主題 IgA nephropathy
キーワード
主題Scheme Other
主題 endothelin
キーワード
主題Scheme Other
主題 renal failure
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Yao, Fei-Fei

× Yao, Fei-Fei

WEKO 51535

Yao, Fei-Fei

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Saito, Noriko

× Saito, Noriko

WEKO 51536

Saito, Noriko

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Narita, Ichiei

× Narita, Ichiei

WEKO 51537

Narita, Ichiei

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Miura, Takayoshi

× Miura, Takayoshi

WEKO 51538

Miura, Takayoshi

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Wada, Masakazu

× Wada, Masakazu

WEKO 51539

Wada, Masakazu

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Goto, Shin

× Goto, Shin

WEKO 51540

Goto, Shin

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Kondo, Daisuke

× Kondo, Daisuke

WEKO 51541

Kondo, Daisuke

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Iguchi, Seitaro

× Iguchi, Seitaro

WEKO 51542

Iguchi, Seitaro

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Sakatsume, Minoru

× Sakatsume, Minoru

WEKO 51543

Sakatsume, Minoru

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Gejyo, Fumitake

× Gejyo, Fumitake

WEKO 51544

Gejyo, Fumitake

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抄録
内容記述タイプ Abstract
内容記述 Endothelin 1 (ET-1) is a potent vasoconstrictor that plays an important role in the progression of renal injury. IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis, is one of the major causes of end stage renal disease (ESRD) and the susceptibility to progressive renal dysfunction in this disease may be determined by genetic variations. In the present study, we investigated 308 patients with biopsy-proven IgAN for possible associations between ET-1 K198N polymorphism and clinical and histopathological manifestations. At the time of biopsy, the ET-1 198KK genotype was significantly associated with a higher incidence of hypertension and lower renal function, and the renal survival of patients with the ET-1 198KK genotype was significantly worse than those with other genotypes. Moreover, with respect to the histopathological characteristics of renal biopsy findings, the 198KK genotype was significantly associated with higher scores of global sclerosis, interstitial fibrosis, and arteriosclerosis of large arteries than other genotypes, whereas no difference was observed in other histological parameters including mesangial cell proliferation, mesangial matrix increase, the adhesion of glomerular tufts to Bowman's capsule, and crescent formation. The results of the present study indicate that the K198N polymorphism can be a marker for severe renal vascular injury and poor renal survival in patients with IgAN.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 56, 号 1, p. 11-17, 発行日 2008-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
権利
権利情報 本文データは学協会の許諾に基づきCiNiiから複製したものである
著者版フラグ
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