WEKO3
アイテム
Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy
http://hdl.handle.net/10191/19596
http://hdl.handle.net/10191/19596bc70398d-08e9-4d9f-a7cf-90c66cee80d5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
110007138517.pdf (632.1 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-28 | |||||
| タイトル | ||||||
| タイトル | Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy | |||||
| タイトル | ||||||
| タイトル | Endothelin-1 K198N Polymorphism Modifies Clinical and Histopathological Manifestations of IgA Nephropathy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgA nephropathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | renal failure | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Yao, Fei-Fei
× Yao, Fei-Fei× Saito, Noriko× Narita, Ichiei× Miura, Takayoshi× Wada, Masakazu× Goto, Shin× Kondo, Daisuke× Iguchi, Seitaro× Sakatsume, Minoru× Gejyo, Fumitake |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Endothelin 1 (ET-1) is a potent vasoconstrictor that plays an important role in the progression of renal injury. IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis, is one of the major causes of end stage renal disease (ESRD) and the susceptibility to progressive renal dysfunction in this disease may be determined by genetic variations. In the present study, we investigated 308 patients with biopsy-proven IgAN for possible associations between ET-1 K198N polymorphism and clinical and histopathological manifestations. At the time of biopsy, the ET-1 198KK genotype was significantly associated with a higher incidence of hypertension and lower renal function, and the renal survival of patients with the ET-1 198KK genotype was significantly worse than those with other genotypes. Moreover, with respect to the histopathological characteristics of renal biopsy findings, the 198KK genotype was significantly associated with higher scores of global sclerosis, interstitial fibrosis, and arteriosclerosis of large arteries than other genotypes, whereas no difference was observed in other histological parameters including mesangial cell proliferation, mesangial matrix increase, the adhesion of glomerular tufts to Bowman's capsule, and crescent formation. The results of the present study indicate that the K198N polymorphism can be a marker for severe renal vascular injury and poor renal survival in patients with IgAN. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 56, 号 1, p. 11-17, 発行日 2008-03 |
|||||
| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
