{"_buckets": {"deposit": "c225bc49-3304-4cf0-bf06-241d0fbfba00"}, "_deposit": {"id": "6183", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6183"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006183", "sets": ["456", "572"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "71", "bibliographicPageStart": "63", "bibliographicVolumeNumber": "56", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Streptococcal toxic shock-like syndrome (TSLS) is one of the fulminant types of toxic infectious diseases caused by Streptococcus pyogenes. Although there are several candidates as the virulence factors including M protein, little is known why TSLS is caused by only some of S. pyogenes strains but not by others. In this study, we compared the cytokine inducing activity in mice between S. pyogenes M-3 type strains derived from TSLS and non-TSLS cases. After infection into mice, TSLS-derived strains persisted longer in the blood than non-TSLS-derived strains. Moreover, TSLS-derived strains were highly capable of inducing proinflammatory cytokines both in vivo and in vitro. TSLS-derived strains also showed a higher ability to produce streptolysin O (SLO). These findings suggest that SLO plays a role as a possible virulence factor accounting for the shock induction in the infected host.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsutsui, Nanako"}], "nameIdentifiers": [{"nameIdentifier": "51509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gejyo, Fumitake"}], "nameIdentifiers": [{"nameIdentifier": "51510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Ikuo"}], "nameIdentifiers": [{"nameIdentifier": "51511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsuyama, Masao"}], "nameIdentifiers": [{"nameIdentifier": "51512", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110007138503.pdf", "filesize": [{"value": "858.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 858500.0, "url": {"label": "110007138503.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6183/files/110007138503.pdf"}, "version_id": "ddd2e04b-03c7-4b5c-86bd-7b8909c4bd32"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Streptococcus pyogenes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TSLS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytokine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases"}, {"subitem_title": "Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "572"], "permalink_uri": "http://hdl.handle.net/10191/19589", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-09-28"}, "publish_date": "2012-09-28", "publish_status": "0", "recid": "6183", "relation": {}, "relation_version_is_last": true, "title": ["Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases"], "weko_shared_id": null}