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Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases
http://hdl.handle.net/10191/19589
http://hdl.handle.net/10191/19589821614c5-1294-463d-9e7d-8027b513b5c3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
110007138503.pdf (858.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-28 | |||||
| タイトル | ||||||
| タイトル | Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases | |||||
| タイトル | ||||||
| タイトル | Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Streptococcus pyogenes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TSLS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokine | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Tsutsui, Nanako
× Tsutsui, Nanako× Gejyo, Fumitake× Kawamura, Ikuo× Mitsuyama, Masao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Streptococcal toxic shock-like syndrome (TSLS) is one of the fulminant types of toxic infectious diseases caused by Streptococcus pyogenes. Although there are several candidates as the virulence factors including M protein, little is known why TSLS is caused by only some of S. pyogenes strains but not by others. In this study, we compared the cytokine inducing activity in mice between S. pyogenes M-3 type strains derived from TSLS and non-TSLS cases. After infection into mice, TSLS-derived strains persisted longer in the blood than non-TSLS-derived strains. Moreover, TSLS-derived strains were highly capable of inducing proinflammatory cytokines both in vivo and in vitro. TSLS-derived strains also showed a higher ability to produce streptolysin O (SLO). These findings suggest that SLO plays a role as a possible virulence factor accounting for the shock induction in the infected host. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 56, 号 2, p. 63-71, 発行日 2008-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
