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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue

http://hdl.handle.net/10191/50291
http://hdl.handle.net/10191/50291
09f46e88-232e-4e24-a463-ee494062108f
名前 / ファイル ライセンス アクション
h30ndo189.pdf 本文 (13.1 MB)
h30ndo189_a.pdf 要旨 (318.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-07-05
タイトル
タイトル Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
タイトル
言語 en
タイトル Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
言語
言語 eng
キーワード
主題Scheme Other
主題 Bromodeoxyuridine
キーワード
主題Scheme Other
主題 Cell differentiation
キーワード
主題Scheme Other
主題 Periodontium
キーワード
主題Scheme Other
主題 Transplantation
キーワード
主題Scheme Other
主題 Mice (Transgenic)
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 他家歯胚移植におけるドナー・ホスト相互作用 : 歯周組織に着目して
著者 Nakaki, Tetsuro

× Nakaki, Tetsuro

WEKO 51371

Nakaki, Tetsuro

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著者別名
識別子 51372
識別子Scheme WEKO
姓名 中木, 哲朗
抄録
内容記述タイプ Abstract
内容記述 Objectives: Limited biological evidence exists regarding donor–host interaction in the periodontal tissue during allogenic tooth germ transplantation. This study aimed to clarify donor–host tissue interactions during periodontal tissue healing following tooth germ transplantation. Methods: This study compared the localization of putative stem cells in the periodontal ligament (PDL) by 5-bromo-2′-deoxyuridine (BrdU), Gli1, and periostin immunoreactions using pulse-chase paradigm (BrdU prenatal labeling: peritoneal pulse injections at embryonic days [E]15–17) in TetOP–H2B–GFP mice (doxycycline administration at E14.5). The current study characterized periodontal tissue healing following allogenic tooth grafts in GFP-labeled donor or host and wild-type mice by pulse-chase paradigm and GFP, BrdU, Gli1, and periostin immunohistochemistry. Results: BrdU prenatal labeling demonstrated that dense label-retaining cells (BrdU–LRCs) disappeared from the PDL by postnatal week 2 (P2W). However, H2B–GFP–LRCs were localized in the PDL of TetOP–H2B–GFP mice during P3–8W, and Gli1-positive cells in the PDL increased at P2–3W, showing that H2B– GFP–LRCs in the PDL are derived from non-proliferating cells during E15–17. Transplanted molars formed cusps and roots and erupted into occlusion by two weeks postoperatively. The junctional epithelium and tooth-related zone of PDL were exclusively composed of donor cells, whereas the PDL alveolar-related zone was a hybrid structure of donor and host cells. Conclusions: The current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15–17, and is composed of resident dental follicle-derived cells and other cell population.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 乙第2224号. 学位記番号: 新大博(歯)乙第189号. 学位授与年月日: 平成30年6月29日
内容記述
内容記述タイプ Other
内容記述 Journal of Oral Biosciences. 2018, 60(1), 21-30.
書誌情報 発行日 2018-06-29
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.job.2018.02.002
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-06-29
学位授与番号
学位授与番号 13101乙第2224号
学位記番号
内容記述タイプ Other
内容記述 新大博(歯)乙第189号
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