{"_buckets": {"deposit": "23a041bc-a734-42c3-9ffa-7be324f9b0c6"}, "_deposit": {"id": "6097", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6097"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006097"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u4ed6\u5bb6\u6b6f\u80da\u79fb\u690d\u306b\u304a\u3051\u308b\u30c9\u30ca\u30fc\u30fb\u30db\u30b9\u30c8\u76f8\u4e92\u4f5c\u7528 : \u6b6f\u5468\u7d44\u7e54\u306b\u7740\u76ee\u3057\u3066"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-06-29", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2018-06-29"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u6b6f\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Objectives: Limited biological evidence exists regarding donor\u2013host interaction in the periodontal tissue during allogenic tooth germ transplantation. This study aimed to clarify donor\u2013host tissue interactions during periodontal tissue healing following tooth germ transplantation. Methods: This study compared the localization of putative stem cells in the periodontal ligament (PDL) by 5-bromo-2\u2032-deoxyuridine (BrdU), Gli1, and periostin immunoreactions using pulse-chase paradigm (BrdU prenatal labeling: peritoneal pulse injections at embryonic days [E]15\u201317) in TetOP\u2013H2B\u2013GFP mice (doxycycline administration at E14.5). The current study characterized periodontal tissue healing following allogenic tooth grafts in GFP-labeled donor or host and wild-type mice by pulse-chase paradigm and GFP, BrdU, Gli1, and periostin immunohistochemistry. Results: BrdU prenatal labeling demonstrated that dense label-retaining cells (BrdU\u2013LRCs) disappeared from the PDL by postnatal week 2 (P2W). However, H2B\u2013GFP\u2013LRCs were localized in the PDL of TetOP\u2013H2B\u2013GFP mice during P3\u20138W, and Gli1-positive cells in the PDL increased at P2\u20133W, showing that H2B\u2013 GFP\u2013LRCs in the PDL are derived from non-proliferating cells during E15\u201317. Transplanted molars formed cusps and roots and erupted into occlusion by two weeks postoperatively. The junctional epithelium and tooth-related zone of PDL were exclusively composed of donor cells, whereas the PDL alveolar-related zone was a hybrid structure of donor and host cells. Conclusions: The current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15\u201317, and is composed of resident dental follicle-derived cells and other cell population.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u6b6f\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u4e59\u7b2c2224\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u535a\uff08\u6b6f\uff09\u4e59\u7b2c189\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621030\u5e746\u670829\u65e5", "subitem_description_type": "Other"}, {"subitem_description": "Journal of Oral Biosciences. 2018, 60(1), 21-30.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": 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"ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakaki, Tetsuro"}], "nameIdentifiers": [{"nameIdentifier": "51371", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30ndo189.pdf", "filesize": [{"value": "13.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 13100000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/6097/files/h30ndo189.pdf"}, "version_id": "89fada9a-a7d9-42aa-9d4a-f1f6447ced3e"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30ndo189_a.pdf", "filesize": [{"value": "318.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 318600.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/6097/files/h30ndo189_a.pdf"}, "version_id": "85b4dd6d-352c-46aa-9b62-fa7cf3c10b22"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Bromodeoxyuridine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell differentiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Periodontium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mice (Transgenic)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Donor\u2013host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Donor\u2013host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue"}, {"subitem_title": "Donor\u2013host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "432/433/434"], "permalink_uri": "http://hdl.handle.net/10191/50291", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-07-05"}, "publish_date": "2018-07-05", "publish_status": "0", "recid": "6097", "relation": {}, "relation_version_is_last": true, "title": ["Donor\u2013host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue"], "weko_shared_id": 2}