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Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice
http://hdl.handle.net/10191/50460
http://hdl.handle.net/10191/50460fd7947d6-870f-42a0-88a6-7252b5f2856a
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本文 (1.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-12-10 | |||||
| タイトル | ||||||
| タイトル | Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice | |||||
| タイトル | ||||||
| タイトル | Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dystonia musculorum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | trigeminal motor nucleus (Mo5) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | motor neuron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurodegeneration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mandibular nerve | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | masseter muscle | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | ジストニアマスキュローラムマウスの咀嚼筋を支配する三叉神経運動核における運動ニューロン変性 | |||||
| 著者 |
Hossain, Md Ibrahim
× Hossain, Md Ibrahim |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dystonia musculorum (dt) mice, which have a mutation in the Dystonin (Dst) gene, are used as animal models to investigate the human disease known as hereditary sensory and autonomic neuropathy type VI. Massive neuronal cell death is observed, mainly in the peripheral nervous system (PNS) of dt mice. We and others have recently reported a histopathological feature of these mice that neurofilament (NF) accumulates in various areas of the central nervous system (CNS), including motor pathways. Although dt mice show motor disorder and growth retardation, the causes for these are still unknown. Here we performed histopathological analyses on motor units of the trigeminal motor nucleus (Mo5 nucleus), because they are a good system to understand neuronal responses in the mutant CNS, and abnormalities in this system may lead to problems in mastication, with subsequent growth retardation. We report that motoneurons with NF accumulation in the Mo5 nuclei of Dst^(Gt) homozygous mice express the stress-induced genes CHOP, ATF3, and lipocalin 2 (Lcn2). We also show a reduced number of Mo5 motoneurons and a reduced size of Mo5 nuclei in Dst^(Gt) homozygous mice, possibly due to apoptosis, given the presence of cleaved caspase 3-positive Mo5 motoneurons. In the mandibular (V3) branches of the trigeminal nerve, which contains axons of Mo5 motoneurons and trigeminal sensory neurons, there was infiltration of Iba1-positive macrophages. Finally, we report atrophy of the masseter muscles in Dst^(Gt) homozygous mice, which showed abnormal nuclear localization of myofibrils and increased expression of atrogin-1 mRNA, a muscle atrophy-related gene and weaker masseter muscle strength with uncontrolled muscle activity by electromyography (EMG). Taken together, our findings strongly suggest that mastication in dt mice is affected due to abnormalities of Mo5 motoneurons and masseter muscles, leading to growth retardation at the post-weaning stages. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4422号. 学位記番号: 新大院博（医）甲第821号. 学位授与年月日: 平成30年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neurochemistry International. Article first published online: 21 October 2017. | |||||
| 書誌情報 | p. 1-26, 発行日 2018-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.neuint.2017.10.009 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4422号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第821号 | |||||
