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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice

http://hdl.handle.net/10191/50460
http://hdl.handle.net/10191/50460
fd7947d6-870f-42a0-88a6-7252b5f2856a
名前 / ファイル ライセンス アクション
h29nmk821.pdf 本文 (1.7 MB)
h29nmk821_a.pdf 要旨 (586.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-12-10
タイトル
タイトル Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice
タイトル
言語 en
タイトル Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in dystonia musculorum mice
言語
言語 eng
キーワード
主題Scheme Other
主題 dystonia musculorum
キーワード
主題Scheme Other
主題 trigeminal motor nucleus (Mo5)
キーワード
主題Scheme Other
主題 motor neuron
キーワード
主題Scheme Other
主題 neurodegeneration
キーワード
主題Scheme Other
主題 mandibular nerve
キーワード
主題Scheme Other
主題 masseter muscle
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル ジストニアマスキュローラムマウスの咀嚼筋を支配する三叉神経運動核における運動ニューロン変性
著者 Hossain, Md Ibrahim

× Hossain, Md Ibrahim

WEKO 175320

Hossain, Md Ibrahim

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抄録
内容記述タイプ Abstract
内容記述 Dystonia musculorum (dt) mice, which have a mutation in the Dystonin (Dst) gene, are used as animal models to investigate the human disease known as hereditary sensory and autonomic neuropathy type VI. Massive neuronal cell death is observed, mainly in the peripheral nervous system (PNS) of dt mice. We and others have recently reported a histopathological feature of these mice that neurofilament (NF) accumulates in various areas of the central nervous system (CNS), including motor pathways. Although dt mice show motor disorder and growth retardation, the causes for these are still unknown. Here we performed histopathological analyses on motor units of the trigeminal motor nucleus (Mo5 nucleus), because they are a good system to understand neuronal responses in the mutant CNS, and abnormalities in this system may lead to problems in mastication, with subsequent growth retardation. We report that motoneurons with NF accumulation in the Mo5 nuclei of Dst^(Gt) homozygous mice express the stress-induced genes CHOP, ATF3, and lipocalin 2 (Lcn2). We also show a reduced number of Mo5 motoneurons and a reduced size of Mo5 nuclei in Dst^(Gt) homozygous mice, possibly due to apoptosis, given the presence of cleaved caspase 3-positive Mo5 motoneurons. In the mandibular (V3) branches of the trigeminal nerve, which contains axons of Mo5 motoneurons and trigeminal sensory neurons, there was infiltration of Iba1-positive macrophages. Finally, we report atrophy of the masseter muscles in Dst^(Gt) homozygous mice, which showed abnormal nuclear localization of myofibrils and increased expression of atrogin-1 mRNA, a muscle atrophy-related gene and weaker masseter muscle strength with uncontrolled muscle activity by electromyography (EMG). Taken together, our findings strongly suggest that mastication in dt mice is affected due to abnormalities of Mo5 motoneurons and masseter muscles, leading to growth retardation at the post-weaning stages.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4422号. 学位記番号: 新大院博(医)甲第821号. 学位授与年月日: 平成30年3月23日
内容記述
内容記述タイプ Other
内容記述 Neurochemistry International. Article first published online: 21 October 2017.
書誌情報 p. 1-26, 発行日 2018-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.neuint.2017.10.009
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-03-23
学位授与番号
学位授与番号 13101甲第4422号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第821号
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