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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan

http://hdl.handle.net/10191/50415
http://hdl.handle.net/10191/50415
af3a3f5d-d00a-4d83-8219-59ada2af93ae
名前 / ファイル ライセンス アクション
h29nmk789.pdf 本文 (294.0 kB)
h29nmk789_a.pdf 要旨 (678.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-07-26
タイトル
タイトル The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan
タイトル
言語 en
タイトル The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan
言語
言語 eng
キーワード
主題Scheme Other
主題 uveal melanoma
キーワード
主題Scheme Other
主題 GNAQ/11 mutation
キーワード
主題Scheme Other
主題 cell types
キーワード
主題Scheme Other
主題 Ki-67
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 日本人ぶどう膜悪性黒色腫症例におけるGNAQ遺伝子及びGNA11遺伝子の変異率と遺伝子変異と臨床病理学的所見との関連についての検討
著者 Ominato, Jun

× Ominato, Jun

WEKO 51202

Ominato, Jun

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著者別名
識別子 51203
識別子Scheme WEKO
姓名 大湊, 絢
抄録
内容記述タイプ Abstract
内容記述 GNAQ and GNA11 mutations are thought to be important for the tumorigenesis of uveal melanoma. Although previous studies have reported on mutation rates in cases of uveal melanoma, presently, no such report for the Japanese population exists. In this study, we examined the frequency of GNAQ and GNA11 somatic mutations in cases of uveal melanoma in Japan and their relationship with clinicopathologic features or Ki-67-positive cell rates (Ki-67 labelingindex: Ki-67 LI) using immunofluorescence methods. The study involved 19 cases of uveal melanoma. We extracted the template DNA from formalin-fixed, paraffin-embedded specimens using a DNA extraction kit. We amplified the DNA sequences of GNAQ and GNA11 using polymerase chain reaction and analyzed mutations by direct sequencing. We evaluated Ki-67 LI using immunofluorescence methods. The frequencies of GNAQ and GNA11 somatic mutations were 26.3% (5/19) and 31.6% (6/19), respectively. The GNAQ and GNA11 mutations were mutually exclusive, as indicated in previous reports. The frequency of GNA11 mutations was significantly higher in epithelioid cells; however, no significant association between GNAQ mutations and cell type was evident, and there was no significant difference in Ki-67 LI between the mutation-positive and mutation-negative tumors. GNAQ and GNA11 mutations were identified in cases of uveal melanoma in Japan, although at lower frequencies than in white counterparts. The mutation frequency of GNA11 was significantly higher in epithelioid cells.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4390号. 学位記番号: 新大院博(医)甲第789号. 学位授与年月日: 平成30年3月23日
内容記述
内容記述タイプ Other
内容記述 Applied Immunohistochemistry & Molecular Morphology. 2017 . Publish Ahead of Print.
書誌情報 p. 1-6, 発行日 2018-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1097/PAI.0000000000000505
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-03-23
学位授与番号
学位授与番号 13101甲第4390号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第789号
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