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Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis
http://hdl.handle.net/10191/50457
http://hdl.handle.net/10191/504577bb47196-df53-45df-8546-0fcb5cbcc770
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本文 (1.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-12-10 | |||||
| タイトル | ||||||
| タイトル | Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis | |||||
| タイトル | ||||||
| タイトル | Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mucosal-associated invariant T cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | primary biliary cholangitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-7 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | exhaustion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ursodeoxycholic acid | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 原発性胆汁性胆管炎における粘膜関連インバリアントT細胞の検討 | |||||
| 著者 |
Setsu, Toru
× Setsu, Toru |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 175319 | |||||
| 姓名 | 薛, 徹 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background & Aim: Mucosal-associated invariant T (MAIT) cells constitute a novel subset of innate-like T-lymphocytes characterized by a semi-invariant T-cell receptor repertoire capable of recognizing bacterial products. Considering the abundance of MAIT cells in the liver and the possible association between bacterial infections and primary biliary cholangitis (PBC), we aimed to analyze the involvement of MAIT cells in the immunopathogenesis of PBC. Methods: Peripheral blood and liver biopsy specimens were collected from 25 patients with PBC and 19 patients with chronic viral hepatitis. Surgically removed liver tissues distant from tumors in patients with metastatic liver tumors were used as controls. Mononuclear cells were separated using Ficoll-gradient, and the expression of various markers was investigated by flow cytometry. Cytokine production was investigated using blood MAIT cells after stimulation by anti-CD3/CD28-coupled beads with/without interleukin-7 (IL-7). Results: MAIT cells were significantly reduced in both the blood and liver of PBC patients compared with those in controls. MAIT cells in the blood of PBC patients expressed significantly lower levels of activation markers and IL-7 receptor. Moreover, MAIT cells in the blood of PBC patients showed impaired production of cytokines, especially tumor necrosis factor-α, after in vitro stimulation with IL-7. Interestingly, even after biochemical responses were achieved by ursodeoxycholic acid (UDCA) treatment, the frequencies of MAIT cells did not fully recover to normal levels. Conclusions: These findings suggested that MAIT cells were activated, exhausted and persistently depleted in PBC patients even after UDCA treatment, possibly as a consequence of persistent liver inflammation. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4382号. 学位記番号: 新大院博（医）甲第781号. 学位授与年月日: 平成30年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Gastroenterology and Hepatology. Article first published online: 21 December 2017. | |||||
| 書誌情報 | 発行日 2018-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1111/jgh.14076 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4382号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第781号 | |||||
