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Patients with persistent hyperglycemia due to glucocorticoid therapy sometimes require insulin therapy that may result in more weight gain and more episodes of hypoglycemia, some of which are severe. On the other hand, scant evidence is available on the efficacy of oral hypoglycemic agents for glucocorticoid-induced diabetes. In this study, we evaluated the efficacy of dipeptidyl peptidase (DPP)-4 inhibitors in patients with glucocorticoid-induced diabetes by continuous glucose monitoring (CGM). Methods We examined glycemic profiles using CGM at baseline and 1–4 weeks after initiating DPP-4 inhibitor treatment in patients with newly developed glucocorticoid-induced diabetes. Results Eleven patients diagnosed with kidney disease or other diseases with renal involvement were recruited for retrospective analysis in this study. After starting DPP-4 inhibitors, the mean and the SD of glucose levels, and the mean amplitude of glycemic excursion (MAGE) were significantly improved compared with baseline. Furthermore, the area over the curve for glucose levels \u003c70 mg/dL was not increased compared with baseline after initiating DPP-4 inhibitors. Treatment of patients with glucocorticoid-induced diabetes using DPP-4 inhibitors can thus minimize the risk of hypoglycemia and reduce glucose variability. 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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring

http://hdl.handle.net/10191/48159
http://hdl.handle.net/10191/48159
5496f22d-f043-4746-a18f-708320af9a4f
名前 / ファイル ライセンス アクション
h29nmk768.pdf 本文 (486.4 kB)
h29nmk768_a.pdf 要旨 (202.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-11-07
タイトル
タイトル Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring
タイトル
言語 en
タイトル Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring
言語
言語 eng
キーワード
主題Scheme Other
主題 dipeptidyl peptidase-4 inhibitor
キーワード
主題Scheme Other
主題 glucocorticoid-induced diabetes
キーワード
主題Scheme Other
主題 continuous glucose monitoring
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 持続血糖モニタリングを用いた糖質コルチコイド起因性糖尿病患者へのDipeptidyl peptidase-4阻害薬の効果の検討
著者 Yata, Yusuke

× Yata, Yusuke

WEKO 51136

Yata, Yusuke

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著者別名
識別子 51137
識別子Scheme WEKO
姓名 矢田, 雄介
抄録
内容記述タイプ Abstract
内容記述 Objective Administration of glucocorticoids usually causes a mild increase in fasting glucose levels and a greater dose-dependent increase in postprandial values in patients without pre-existing diabetes mellitus. Patients with persistent hyperglycemia due to glucocorticoid therapy sometimes require insulin therapy that may result in more weight gain and more episodes of hypoglycemia, some of which are severe. On the other hand, scant evidence is available on the efficacy of oral hypoglycemic agents for glucocorticoid-induced diabetes. In this study, we evaluated the efficacy of dipeptidyl peptidase (DPP)-4 inhibitors in patients with glucocorticoid-induced diabetes by continuous glucose monitoring (CGM). Methods We examined glycemic profiles using CGM at baseline and 1–4 weeks after initiating DPP-4 inhibitor treatment in patients with newly developed glucocorticoid-induced diabetes. Results Eleven patients diagnosed with kidney disease or other diseases with renal involvement were recruited for retrospective analysis in this study. After starting DPP-4 inhibitors, the mean and the SD of glucose levels, and the mean amplitude of glycemic excursion (MAGE) were significantly improved compared with baseline. Furthermore, the area over the curve for glucose levels <70 mg/dL was not increased compared with baseline after initiating DPP-4 inhibitors. Treatment of patients with glucocorticoid-induced diabetes using DPP-4 inhibitors can thus minimize the risk of hypoglycemia and reduce glucose variability. Conclusion DPP-4 inhibitors are potentially useful for blood glucose control in patients with glucocorticoid-induced diabetes.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4355号. 学位記番号: 新大院博(医)甲第768号. 学位授与年月日: 平成29年9月20日
内容記述
内容記述タイプ Other
内容記述 The Assessment of the Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Glucocorticoid-induced Diabetes by Continuous Glucose Monitoring. Internal Medicine. 2017, 56(19), 2555-2562.
書誌情報 p. 1-24, 発行日 2017-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.2169/internalmedicine.8296-16
権利
権利情報 (C) 2017 by The Japanese Society of Internal Medicine
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-09-20
学位授与番号
学位授与番号 13101甲第4355号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第768号
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