WEKO3
アイテム
Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study
http://hdl.handle.net/10191/48145
http://hdl.handle.net/10191/4814505c3bfcc-7e9b-4b0e-b9a9-b31111416f43
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要旨 (186.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-16 | |||||
| タイトル | ||||||
| タイトル | Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study | |||||
| タイトル | ||||||
| タイトル | Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | amygdala | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bcl-2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hippocampal sclerosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HSP70 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mesial temporal epilepsy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 内側側頭葉てんかんおよび海馬硬化症における扁桃体の体積定量および病理組織学的研究 | |||||
| 著者 |
Nakayama, Yoko
× Nakayama, Yoko |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 175309 | |||||
| 姓名 | 中山, 遥子 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: It is well-known that there is a correlation between the neuropathological grade of hippocampal sclerosis (HS) and neuroradiological atrophy of the hippocampus in mesial temporal lobe epilepsy (mTLE) patients. However, there is no strict definition or criterion regarding neuron loss and atrophy of the amygdala neighboring the hippocampus. We examined the relationship between HS and neuronal loss in the amygdala. Materials and Methods: Nineteen mTLE patients with neuropathological proof of HS were assigned to Group A, while seven mTLE patients without HS were assigned to Group B. We used FreeSurfer software to measure amygdala volume automatically based on pre-operation magnetic resonance images. Neurons observed using Kluver-Barrera (KB) staining in resected amygdala tissue were counted. and the extent of immunostaining with stress marker antibodies was semiquantitatively evaluated. Results: There was no significant difference in amygdala volume between the two groups (Group A: 1.41 ± 0.24; Group B: 1.41 ± 0.29 cm^3; p= 0.98), nor in the neuron cellularity of resected amygdala specimens (Group A: 3.98 ± 0.97; Group B: 3.67 ± 0.67 10×^<-4> number of neurons/μm^2; p= 0.40). However, the HSP70 level, representing acute stress against epilepsy, in Group A patients was significantly larger than that in Group B. There was no significant difference in the level of Bcl-2, which is known as a protein that inhibits cell death, between the two groups. Conclusions: Neuronal loss and volume loss in the amygdala may not necessarily follow hippocampal sclerosis. From the analysis of stress proteins, epileptic attacks are as likely to damage the amygdala as the hippocampus but do not lead to neuronal death in the amygdala. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4353号. 学位記番号: 新大院博（医）甲第766号. 学位授与年月日: 平成29年9月20日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Epilepsy Research. 2017, 135, 50-55. | |||||
| 書誌情報 | 発行日 2017-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.eplepsyres.2017.05.010 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4353号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第766号 | |||||
