WEKO3
アイテム
{"_buckets": {"deposit": "dad30418-6e7f-4c21-95a7-2d6d99d4fc1f"}, "_deposit": {"id": "5946", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5946"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005946", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "完全閉じ込め状態(communication stage V)に至った筋萎縮性側索硬化症例の臨床病理学的特徴"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In the present study, we performed a comprehensive analysis to clarify the clinicopathological characteristics of patients with amyotrophic lateral sclerosis (ALS) that had progressed to result in a totally locked-in state (communication Stage V), in which all voluntary movements are lost and communication is impossible. In 11 patients, six had phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI), two had fused in sarcoma (FUS)-ir NCI, and three had copper/zinc superoxide dismutase (SOD1)-ir NCI. The time from ALS onset to the need for tracheostomy invasive ventilation was less than 24 months in ten patients. Regardless of accumulated protein, all the patients showed common lesions in the pallido–nigro–luysian system, brainstem reticular formation, and cerebellar efferent system, in addition to motor neurons. In patients with pTDP-43-ir NCI, patients with NCI in the hippocampal dentate granule neurons (DG) showed a neuronal loss in the cerebral cortex, and patients without NCI in DG showed a preserved cerebral cortex. By contrast, in patients with FUS-ir NCI, patients with NCI in DG showed a preserved cerebral cortex and patients without NCI in DG showed marked cerebral degeneration. The cerebral cortex of patients with SOD1-ir NCI was preserved. Together, these findings suggest that lesions of the cerebrum are probably not necessary for progression to Stage V. In conclusion, patients with ALS that had progressed to result in communication Stage V showed rapidly-progressed symptoms, and their common lesions could cause the manifestations of communication Stage V.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士(医学). 報告番号: 甲第4350号. 学位記番号: 新大院博(医)甲第763号. 学位授与年月日: 平成29年9月20日", "subitem_description_type": "Other"}, {"subitem_description": "Acta Neuropathologica Communications. 2016, 4, 107.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第763号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4350号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "51127", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "林, 健太郎"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1186/s40478-016-0379-3", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "(C) 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi, Kentaro"}], "nameIdentifiers": [{"nameIdentifier": "51126", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h29nmk763.pdf", "filesize": [{"value": "3.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3900000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/5946/files/h29nmk763.pdf"}, "version_id": "6714d33f-5222-4b0c-a9a9-4bc9646ca2c3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h29nmk763_a.pdf", "filesize": [{"value": "202.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 202500.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/5946/files/h29nmk763_a.pdf"}, "version_id": "81c6ee3a-9be0-4733-87fa-7ccfc6a85694"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Amyotrophic lateral sclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Communication Stage V", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Totally locked-in state", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pallido-nigro-luysian system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Brainstem reticular formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cerebral cortical degeneration", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)"}, {"subitem_title": "Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/48148", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-07"}, "publish_date": "2017-11-07", "publish_status": "0", "recid": "5946", "relation": {}, "relation_version_is_last": true, "title": ["Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)"], "weko_shared_id": 2}
Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)
http://hdl.handle.net/10191/48148
http://hdl.handle.net/10191/48148f4da177c-ac42-4498-b18b-51abca4e18aa
名前 / ファイル | ライセンス | アクション |
---|---|---|
本文 (3.9 MB)
|
|
|
要旨 (202.5 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-11-07 | |||||
タイトル | ||||||
タイトル | Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amyotrophic lateral sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Communication Stage V | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Totally locked-in state | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pallido-nigro-luysian system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brainstem reticular formation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebral cortical degeneration | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 完全閉じ込め状態(communication stage V)に至った筋萎縮性側索硬化症例の臨床病理学的特徴 | |||||
著者 |
Hayashi, Kentaro
× Hayashi, Kentaro |
|||||
著者別名 | ||||||
識別子 | 51127 | |||||
識別子Scheme | WEKO | |||||
姓名 | 林, 健太郎 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the present study, we performed a comprehensive analysis to clarify the clinicopathological characteristics of patients with amyotrophic lateral sclerosis (ALS) that had progressed to result in a totally locked-in state (communication Stage V), in which all voluntary movements are lost and communication is impossible. In 11 patients, six had phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI), two had fused in sarcoma (FUS)-ir NCI, and three had copper/zinc superoxide dismutase (SOD1)-ir NCI. The time from ALS onset to the need for tracheostomy invasive ventilation was less than 24 months in ten patients. Regardless of accumulated protein, all the patients showed common lesions in the pallido–nigro–luysian system, brainstem reticular formation, and cerebellar efferent system, in addition to motor neurons. In patients with pTDP-43-ir NCI, patients with NCI in the hippocampal dentate granule neurons (DG) showed a neuronal loss in the cerebral cortex, and patients without NCI in DG showed a preserved cerebral cortex. By contrast, in patients with FUS-ir NCI, patients with NCI in DG showed a preserved cerebral cortex and patients without NCI in DG showed marked cerebral degeneration. The cerebral cortex of patients with SOD1-ir NCI was preserved. Together, these findings suggest that lesions of the cerebrum are probably not necessary for progression to Stage V. In conclusion, patients with ALS that had progressed to result in communication Stage V showed rapidly-progressed symptoms, and their common lesions could cause the manifestations of communication Stage V. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4350号. 学位記番号: 新大院博(医)甲第763号. 学位授与年月日: 平成29年9月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Neuropathologica Communications. 2016, 4, 107. | |||||
書誌情報 | 発行日 2017-09-20 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1186/s40478-016-0379-3 | |||||
権利 | ||||||
権利情報 | (C) 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4350号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第763号 |