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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)

http://hdl.handle.net/10191/48148
http://hdl.handle.net/10191/48148
f4da177c-ac42-4498-b18b-51abca4e18aa
名前 / ファイル ライセンス アクション
h29nmk763.pdf 本文 (3.9 MB)
h29nmk763_a.pdf 要旨 (202.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-11-07
タイトル
タイトル Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)
タイトル
言語 en
タイトル Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication stage V)
言語
言語 eng
キーワード
主題Scheme Other
主題 Amyotrophic lateral sclerosis
キーワード
主題Scheme Other
主題 Communication Stage V
キーワード
主題Scheme Other
主題 Totally locked-in state
キーワード
主題Scheme Other
主題 Pallido-nigro-luysian system
キーワード
主題Scheme Other
主題 Brainstem reticular formation
キーワード
主題Scheme Other
主題 Cerebral cortical degeneration
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 完全閉じ込め状態(communication stage V)に至った筋萎縮性側索硬化症例の臨床病理学的特徴
著者 Hayashi, Kentaro

× Hayashi, Kentaro

WEKO 51126

Hayashi, Kentaro

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著者別名
識別子 51127
識別子Scheme WEKO
姓名 林, 健太郎
抄録
内容記述タイプ Abstract
内容記述 In the present study, we performed a comprehensive analysis to clarify the clinicopathological characteristics of patients with amyotrophic lateral sclerosis (ALS) that had progressed to result in a totally locked-in state (communication Stage V), in which all voluntary movements are lost and communication is impossible. In 11 patients, six had phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI), two had fused in sarcoma (FUS)-ir NCI, and three had copper/zinc superoxide dismutase (SOD1)-ir NCI. The time from ALS onset to the need for tracheostomy invasive ventilation was less than 24 months in ten patients. Regardless of accumulated protein, all the patients showed common lesions in the pallido–nigro–luysian system, brainstem reticular formation, and cerebellar efferent system, in addition to motor neurons. In patients with pTDP-43-ir NCI, patients with NCI in the hippocampal dentate granule neurons (DG) showed a neuronal loss in the cerebral cortex, and patients without NCI in DG showed a preserved cerebral cortex. By contrast, in patients with FUS-ir NCI, patients with NCI in DG showed a preserved cerebral cortex and patients without NCI in DG showed marked cerebral degeneration. The cerebral cortex of patients with SOD1-ir NCI was preserved. Together, these findings suggest that lesions of the cerebrum are probably not necessary for progression to Stage V. In conclusion, patients with ALS that had progressed to result in communication Stage V showed rapidly-progressed symptoms, and their common lesions could cause the manifestations of communication Stage V.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4350号. 学位記番号: 新大院博(医)甲第763号. 学位授与年月日: 平成29年9月20日
内容記述
内容記述タイプ Other
内容記述 Acta Neuropathologica Communications. 2016, 4, 107.
書誌情報 発行日 2017-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1186/s40478-016-0379-3
権利
権利情報 (C) 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-09-20
学位授与番号
学位授与番号 13101甲第4350号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第763号
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