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Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer
http://hdl.handle.net/10191/48147
http://hdl.handle.net/10191/4814736c7ec92-d8e5-4f1c-a23d-8613952eb9d1
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本文3 (35.5 kB)
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本文2 (5.6 MB)
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本文1 (3.9 MB)
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要旨 (198.8 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-11-07 | |||||
タイトル | ||||||
タイトル | Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endometrial cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p21 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sex-determining region Y-box 2 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | Sox2によるp21抑制機構は子宮体がんの予後不良因子となる | |||||
著者 |
Yamawaki, Kaoru
× Yamawaki, Kaoru |
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著者別名 | ||||||
識別子 | 51125 | |||||
識別子Scheme | WEKO | |||||
姓名 | 山脇, 芳 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions in advanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4349号. 学位記番号: 新大院博(医)甲第762号. 学位授与年月日: 平成29年9月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Science. 2017, 108(4), 632-640. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The definitive version is available at www.wileyonlinelibrary.com/journal/cas | |||||
書誌情報 | 発行日 2017-09-20 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/cas.13196 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4349号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第762号 |