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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer

http://hdl.handle.net/10191/48147
http://hdl.handle.net/10191/48147
36c7ec92-d8e5-4f1c-a23d-8613952eb9d1
名前 / ファイル ライセンス アクション
h29nmk762-4.pdf 本文4 (241.7 kB)
h29nmk762-3.pdf 本文3 (35.5 kB)
h29nmk762-2.pdf 本文2 (5.6 MB)
h29nmk762-1.pdf 本文1 (3.9 MB)
h29nmk762_a.pdf 要旨 (198.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-11-07
タイトル
タイトル Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer
タイトル
言語 en
タイトル Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 Biomarker
キーワード
主題Scheme Other
主題 cell cycle
キーワード
主題Scheme Other
主題 endometrial cancer
キーワード
主題Scheme Other
主題 p21
キーワード
主題Scheme Other
主題 sex-determining region Y-box 2
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル Sox2によるp21抑制機構は子宮体がんの予後不良因子となる
著者 Yamawaki, Kaoru

× Yamawaki, Kaoru

WEKO 51124

Yamawaki, Kaoru

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著者別名
識別子 51125
識別子Scheme WEKO
姓名 山脇, 芳
抄録
内容記述タイプ Abstract
内容記述 Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions in advanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4349号. 学位記番号: 新大院博(医)甲第762号. 学位授与年月日: 平成29年9月20日
内容記述
内容記述タイプ Other
内容記述 Cancer Science. 2017, 108(4), 632-640.
内容記述
内容記述タイプ Other
内容記述 The definitive version is available at www.wileyonlinelibrary.com/journal/cas
書誌情報 発行日 2017-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1111/cas.13196
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-09-20
学位授与番号
学位授与番号 13101甲第4349号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第762号
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