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Possible involvement of chemokine C-C receptor 7- programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis.
http://hdl.handle.net/10191/48143
http://hdl.handle.net/10191/481438cae0b4b-6aa3-4833-975c-b3b15164e949
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本文 (813.1 kB)
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要旨 (214.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-07-27 | |||||
| タイトル | ||||||
| タイトル | Possible involvement of chemokine C-C receptor 7- programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis. | |||||
| タイトル | ||||||
| タイトル | Possible involvement of chemokine C-C receptor 7- programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | follicular helper T cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | autoimmune hepatitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | primary biliary cholangitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | programmed cell death-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-21 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 自己免疫性肝疾患の免疫病態における CCR7- PD-1+濾胞性ヘルパーT細胞の関与 | |||||
| 著者 |
Kimura, Naruhiro
× Kimura, Naruhiro |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 51123 | |||||
| 姓名 | 木村, 成宏 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background & Aim: Recent studies have demonstrated that B cells and follicular helper T (Tfh) cells, which are central regulators of humoral immune response, contribute to the development and progression of autoimmune diseases. Because Tfh cells can be divided into several subsets with distinct functional properties, this study aimed to examine the roles of different subsets of circulating Tfh cells in the immune pathogenesis of autoimmune hepatitis (AIH). Methods: Thirty-five patients with AIH, 28 patients with primary biliary cholangitis, 24 patients with chronic hepatitis B (CHB), and 44 health controls (HC) were enrolled. The frequencies of different Tfh subsets in the blood and liver were examined by flow cytometry and immunohistochemical staining. The function of circulating Tfh subsets was examined after in vitro stimulation. Results: In newly diagnosed AIH patients, the frequency of circulating chemokine C-C receptor 7 (CCR7)- programmed cell death-1 (PD-1)+ Tfh subset was significantly increased compared with that in CHB patients and HC, significantly correlated with clinical parameters, including serum IgG, prothrombin time and albumin levels, and significantly decreased after corticosteroid treatment. In the liver of AIH patients, the frequencies of activated Tfh subsets were significantly increased and positively correlated with those in the blood. Moreover, the ability to produce interleukin (IL)-21 and IL-17 from circulating Tfh cells was significantly increased in AIH patients compared with HC. Conclusions: These results significantly extend our understanding of Tfh subsets in AIH, and suggest a potential role of dysregulated CCR7-PD-1+ Tfh subset in the pathogenesis and disease progression of AIH. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4348号. 学位記番号: 新大院博（医）甲第761号. 学位授与年月日: 平成29年9月20日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Gastroenterology and Hepatology. 2018. 33(1), 298-306. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This is the peer reviewed version of the following article: Journal of Gastroenterology and Hepatology. 2018. 33(1), 298-306, which has been published in final form at DOI: 10.1111/jgh.13844. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. | |||||
| 書誌情報 | 発行日 2017-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1111/jgh.13844 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4348号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第761号 | |||||
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Cite as
Kimura, Naruhiro, 2017, Possible involvement of chemokine C-C receptor 7- programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis.: 新潟大学.
