{"_buckets": {"deposit": "ed598bd6-75d3-435d-8e6c-ebd5559e1f19"}, "_deposit": {"id": "5864", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5864"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005864"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u5c0f\u5150QT\u5ef6\u9577\u75c7\u5019\u7fa4 : KCNH2\u5909\u7570\u4fdd\u6301\u8005\u306e\u767a\u75c7\u306f\u9045\u3044\u304c\u91cd\u75c7\u3067\u3042\u308b"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background:In children with long QT syndrome (LQTS), risk factors for cardiac events have been reported, but age-, gender- and genotype-related differences in prognosis remain unknown in Asian countries.Methods\u2004and\u2004Results:The study examined clinical prognosis at age between 1 and 20 years in 496 LQTS patients who were genotyped as either of LQT1\u20133 (male, n=206). Heterozygous mutations were observed in 3 major responsible genes:KCNQ1in271,KCNH2in 192, andSCN5Ain 33 patients. LQTS-associated events were classified into 3 categories: (1) syncope (n=133); (2) repetitive torsade de pointes (TdP, n=3); and (3) cardiopulmonary arrest (CPA, n=4). The risk of cardiac events was significantly lower in LQT1 girls than boys\u226412 years (HR, 0.55), whereas LQT2 female patients \u226513 years had the higher risk of cardiac events than male patients (HR, 4.60). Patients in the repetitive TdP or CPA group included 1 LQT1 female patient, 1 LQT2 male patient, and 5 LQT2 female patients. All LQT2 patients in these groups had TdP repeatedly immediately after the antecedent event. In addition, all 5 female LQT2 patients in these groups had the event after or near puberty.Conclusions:Female LQT2 children might have repeated TdP shortly after prior events, especially after puberty", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c4276\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c.754\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621029\u5e743\u670823\u65e5", "subitem_description_type": "Other"}, {"subitem_description": "Circulation Journal 2016; 80(3): 696\u2013702", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": 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JAPANESE CIRCULATION SOCIETY"}, {"subitem_rights": "\u4e00\u822c\u793e\u56e3\u6cd5\u4eba\u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a"}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ozawa, Junichi"}], "nameIdentifiers": [{"nameIdentifier": "51004", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h28nmk754.pdf", "filesize": [{"value": "893.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 893700.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/5864/files/h28nmk754.pdf"}, "version_id": "62078548-3eb1-4860-8a72-254111ed983e"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h28nmk754_a.pdf", "filesize": [{"value": "193.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 193400.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/5864/files/h28nmk754_a.pdf"}, "version_id": "93281aa8-7325-415b-8093-e404d5390bd6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Child", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Long QT syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sex hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Torsade de pointes", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms.", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms."}, {"subitem_title": "Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/47626", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-09-11"}, "publish_date": "2018-09-11", "publish_status": "0", "recid": "5864", "relation": {}, "relation_version_is_last": true, "title": ["Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms."], "weko_shared_id": 2}