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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms.

http://hdl.handle.net/10191/47626
http://hdl.handle.net/10191/47626
f0b4bed5-2bd8-45ff-8d26-6cfded5027c0
名前 / ファイル ライセンス アクション
h28nmk754.pdf 本文 (893.7 kB)
h28nmk754_a.pdf 要旨 (193.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms.
タイトル
言語 en
タイトル Pediatric cohort with long QT syndrome : KCNH2 mutation carriers present late onset but severe symptoms.
言語
言語 eng
キーワード
主題Scheme Other
主題 Child
キーワード
主題Scheme Other
主題 Genetics
キーワード
主題Scheme Other
主題 Long QT syndrome
キーワード
主題Scheme Other
主題 Sex hormone
キーワード
主題Scheme Other
主題 Torsade de pointes
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 小児QT延長症候群 : KCNH2変異保持者の発症は遅いが重症である
著者 Ozawa, Junichi

× Ozawa, Junichi

WEKO 51004

Ozawa, Junichi

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著者別名
識別子 51005
識別子Scheme WEKO
姓名 小澤, 淳一
抄録
内容記述タイプ Abstract
内容記述 Background:In children with long QT syndrome (LQTS), risk factors for cardiac events have been reported, but age-, gender- and genotype-related differences in prognosis remain unknown in Asian countries.Methods and Results:The study examined clinical prognosis at age between 1 and 20 years in 496 LQTS patients who were genotyped as either of LQT1–3 (male, n=206). Heterozygous mutations were observed in 3 major responsible genes:KCNQ1in271,KCNH2in 192, andSCN5Ain 33 patients. LQTS-associated events were classified into 3 categories: (1) syncope (n=133); (2) repetitive torsade de pointes (TdP, n=3); and (3) cardiopulmonary arrest (CPA, n=4). The risk of cardiac events was significantly lower in LQT1 girls than boys≤12 years (HR, 0.55), whereas LQT2 female patients ≥13 years had the higher risk of cardiac events than male patients (HR, 4.60). Patients in the repetitive TdP or CPA group included 1 LQT1 female patient, 1 LQT2 male patient, and 5 LQT2 female patients. All LQT2 patients in these groups had TdP repeatedly immediately after the antecedent event. In addition, all 5 female LQT2 patients in these groups had the event after or near puberty.Conclusions:Female LQT2 children might have repeated TdP shortly after prior events, especially after puberty
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4276号. 学位記番号: 新大院博(医)甲第.754号. 学位授与年月日: 平成29年3月23日
内容記述
内容記述タイプ Other
内容記述 Circulation Journal 2016; 80(3): 696–702
書誌情報 発行日 2017-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1253/circj.CJ-15-0933
権利
権利情報 Copyright © 2016 THE JAPANESE CIRCULATION SOCIETY
権利
権利情報 一般社団法人日本循環器学会
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-03-23
学位授与番号
学位授与番号 13101甲第4276号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第754号
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