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Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.
http://hdl.handle.net/10191/47592
http://hdl.handle.net/10191/475925f20b78a-8e67-4bbd-b9ba-97f1a7641da7
| 名前 / ファイル | ライセンス | アクション |
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本文 (676.3 kB)
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要旨 (182.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-09-11 | |||||
| タイトル | ||||||
| タイトル | Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation. | |||||
| タイトル | ||||||
| タイトル | Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Killer immunoglobulin-like receptor haplotype | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Acute graft-versus-host disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Allogeneic hematopoietic cell transplantation | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | ドナーKIRハプロタイプB/xはHLA不一致T細胞非除去造血幹細胞移植において重症急性GVHDを引き起こす | |||||
| 著者 |
Hosokai, Ryosuke
× Hosokai, Ryosuke |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50980 | |||||
| 姓名 | 細貝, 亮介 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Natural killer cells have been identified as a mediator of alloimmune reactions in allogeneic hematopoietic stem cell transplantation (HSCT). Killer immunoglobulin-like receptors (KIRs) are an important determinant of natural killer cell function. The relationship between KIR genotypes/haplotypes and clinical outcomes of allogeneic HSCT is complex and inconsistent among several reports. We assessed the clinical impact of KIR haplotype on T cell–replete allogeneic HSCTs performed in a single Japanese center for hematological malignancies (n = 106). A comparison of 2 groups, donor haplotypes A/A and B/x, revealed no significant differences in overall survival, relapse, and nonrelapse mortality. However, grade III to IV acute graft-versus-host disease (GVHD) occurred significantly more frequently in the KIR haplotype B/x group (A/A versus B/x: 4.9% versus 20.0%; P = .02). This was even more evident when HLA mismatch was present. The highest incidences of grade II to IV and grade III to IV acute GVHD were observed in patients who received allografts from HLA-mismatched donors with KIR haplotype B/x. These data highlight the importance of KIR genotyping in donor matching, especially when HLA mismatch allogeneic grafting is planned. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4261号. 学位記番号: 新大院博（医）甲第739号. 学位授与年月日: 平成29年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biology of Blood and Marrow Transplantation 23(4)606-611,2017 | |||||
| 書誌情報 | 発行日 2017-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.bbmt.2016.12.638 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 Published by Elsevier Inc. on behalf of the American Society for Blood and Marrow Transplantation. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4261号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第739号 | |||||
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Cite as
Hosokai, Ryosuke, 2017, Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.: 新潟大学.
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