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Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia
http://hdl.handle.net/10191/47589
http://hdl.handle.net/10191/4758936973ff7-25c2-4483-968c-b32392a0518b
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本文 (2.0 MB)
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要旨 (167.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2017-10-17 | |||||
| タイトル | ||||||
| タイトル | Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia | |||||
| タイトル | ||||||
| タイトル | Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | achalasia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | high-resolution manometry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interstitial cells of Cajal | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | peroral endoscopic myotomy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | primary esophageal motility disorders | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 内視鏡的食道筋層生検(Peroral esophageal muscle biopsy : POEM-b)による食道運動障害筋層の組織学的検討 : High resolution manometry(HRM)所見との比較 | |||||
| 著者 |
Nakajima, Nao
× Nakajima, Nao |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50975 | |||||
| 姓名 | 中島, 尚 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | "Background : Histopathology of muscularis externa in primary esophageal motility disorders has been characterized previously. We aimed to correlate the results of high-resolution manometry with those of histopathology.\nMethods : During peroral endoscopic myotomy, peroral esophageal muscle biopsy was performed in patients with primary esophageal motility disorders. Immunohistochemical staining for c-kit was performed to assess the interstitial cells of Cajal (ICCs). Hematoxylin Eosin and Azan-Mallory staining were used to detect muscle atrophy, inflammation, and fibrosis, respectively.\nKey Results : Slides from 30 patients with the following motility disorders were analyzed: achalasia (type I: 14, type II: 5, type III: 3), one diffuse esophageal spasm (DES), two outflow obstruction (OO), four jackhammer esophagus (JE), and one nutcracker esophagus (NE). ICCs were preserved in high numbers in type III achalasia (n=9.4±1.2 cells/high power field [HPF]), compared to types I (n=3.7±0.3 cells/HPF) and II (n=3.5±1.0 cells/HPF). Moreover, severe fibrosis was only observed in type I achalasia and not in other types of achalasia, OO, or DES. Four of five patients with JE and NE had severe inflammation with eosinophilic infiltration of the esophageal muscle layer (73.8±50.3 eosinophils/HPF) with no epithelial eosinophils. One patient with JE showed a visceral myopathy pattern.\nConclusions & Inferences : Compared to types I and II, type III achalasia showed preserved ICCs, with variable data regarding DES and OO. In disorders considered as primary esophageal motility disorders, a disease category exists, which shows eosinophilic infiltration in the esophageal muscle layer with no eosinophils in the epithelium. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4258号. 学位記番号: 新大院博（医）甲第736号. 学位授与年月日: 平成29年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neurogastroenterology and Motility 29(3) 2017 | |||||
| 書誌情報 | 発行日 2017-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1111/nmo.12968 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4258号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第736号 | |||||
