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Aberrant Expression of the Tight Junction Molecules Claudin-1 and Zonula Occludens-1 Mediates Cell Growth and Invasion in Oral Squamous Cell Carcinoma
http://hdl.handle.net/10191/45108
http://hdl.handle.net/10191/45108daf9977c-10b2-4167-bbcf-e3e7730723be
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本文 (40.1 MB)
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要旨 (124.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2016-12-07 | |||||
| タイトル | ||||||
| タイトル | Aberrant Expression of the Tight Junction Molecules Claudin-1 and Zonula Occludens-1 Mediates Cell Growth and Invasion in Oral Squamous Cell Carcinoma | |||||
| タイトル | ||||||
| タイトル | Aberrant Expression of the Tight Junction Molecules Claudin-1 and Zonula Occludens-1 Mediates Cell Growth and Invasion in Oral Squamous Cell Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oral mucosa | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | squamous cell carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | carcinoma in-situ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | claudin-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | zonula occludens-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tight junction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell growth | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | invasion | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 口腔扁平上皮癌におけるタイト結合分子Claudin-1およびZonula Occludens-1の異常発現はがん細胞の増殖と浸潤を亢進させる | |||||
| 著者 |
Babkair, Hamzah Ali O
× Babkair, Hamzah Ali O |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We reported that altered cell contact mediated by E-cadherin is an initial event in the pathogenesis of oral epithelial malignancies. To assess other effects of cell adhesion, we examined the expression levels of tight junction (TJ) molecules in oral carcinoma in-situ (CIS) and squamous cell carcinoma (SCC). To identify changes in the expression of TJ molecules, we conducted an analysis of the immunohistochemical profiles of claudin-1(CLDN-1) and zonula occludens-1 (ZO-1) in surgical specimens acquired from patients with oral SCC containing foci of epithelial dysplasia or from patients with CIS. We used\nimmunofluorescence, western blotting, reverse transcriptase-polymerase chain reaction, and RNA interference (RNAi) to evaluate the functions of CLDN-1 and ZO-1 in cultured oral SCC cells. TJ molecules were not detected in normal oral epithelial tissues but were expressed in SCC/CIS cells. ZO-1 was localized within the nucleus of proliferating cells. When CLDN-1 expression was inhibited by transfecting cells with specific small interference RNAs,\nSCC cells dissociated, and their ability to proliferate and invade Matrigel was inhibited. In contrast, although RNAi-mediated inhibition of ZO-1 expression did not affect cell morphology, it inhibited cell proliferation and invasiveness. Our findings indicated that the detection of TJ molecules in the oral epithelia may serve as a marker for the malignant phenotype of cells in which CLDN-1 regulates proliferation and invasion. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（歯学）. 報告番号: 甲第4222号. 学位記番号: 新大院博（歯）甲第364号. 学位授与年月日: 平成28年9月20日 | |||||
| 書誌情報 | 発行日 2016-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4222号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（歯）甲第364号 | |||||
