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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Disrupted Bone Metabolism in Long-Term Bedridden Patients

http://hdl.handle.net/10191/45099
http://hdl.handle.net/10191/45099
28ec8e73-9ae0-4bcb-b7b0-cb7d725bbd18
名前 / ファイル ライセンス アクション
h28nmk712.PDF 本文 (1.1 MB)
h28nmk712_a.pdf 要旨 (202.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Disrupted Bone Metabolism in Long-Term Bedridden Patients
タイトル
言語 en
タイトル Disrupted Bone Metabolism in Long-Term Bedridden Patients
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 長期寝たきり患者における骨代謝障害
著者 Eimori, Keiko

× Eimori, Keiko

WEKO 50902

Eimori, Keiko

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著者別名
識別子 50903
識別子Scheme WEKO
姓名 榮森, 景子
抄録
内容記述タイプ Abstract
内容記述 Background : Bedridden patients are at risk of osteoporosis and fractures, although the long-term bone metabolic processes in these patients are poorly understood. Therefore, we aimed to determine how long-term bed confinement affects bone metabolism.Methods : This study included 36 patients who had been bedridden from birth due to severe immobility.Bone mineral density and bone metabolism markers were compared to the bedridden period in all study patients. Changes in the bone metabolism markers during a follow-up of 12 years were studied in 17 patients aged <30 years at baseline.Results : \nThe bone mineral density was reduced (0.58±0.19 g/cm3), and the osteocalcin (13.9±12.4ng/mL) and urine N-terminal telopeptide (NTX) levels (146.9±134.0 mM BCE/mM creatinine)were greater than the cutoff value for predicting fracture. Among the bone metabolism markers studied, osteocalcin and NTX were negatively associated with the bedridden period. During the follow-up, osteocalcin and parathyroid hormone were decreased, and the 25(OH) vitamin D was increased. NTX at baseline was negatively associated with bone mineral density after 12 years. Conclusions : Unique bone metabolic abnormalities were found in patients who had been bedridden for long periods, and these metabolic abnormalities were altered by further bed confinement.\nAppropriate treatment based on the unique bone metabolic changes may be important in long-term bedridden patients.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4213号. 学位記番号: 新大院博(医)甲第712号. 学位授与年月日: 平成28年9月20日
内容記述
内容記述タイプ Other
内容記述 PLoS ONE 11(6): e0156991
書誌情報 発行日 2016-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1371/journal.pone.0156991
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2016-09-20
学位授与番号
学位授与番号 13101甲第4213号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第712号
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